GTB-3550 tri-specific killer engager safely activates and delivers IL-15 to NK cells, but not T-cells, in immune suppressed patients with advanced myeloid malignancies, a novel paradigm exportable to solid tumors expressing Her2 or B7H3

被引:3
|
作者
Miller, J. S. [1 ]
Warlick, E. D. [1 ]
Wangen, R. [2 ]
Zorko, N. [3 ]
Hinderlie, P. [1 ]
Lewis, D. [1 ]
Vallera, D. A. [4 ]
Felices, M. [1 ]
机构
[1] Univ Minnesota, Masonic Canc Ctr, Med, Minneapolis, MN USA
[2] Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA
[3] Univ Minnesota, Hematol Oncol & Transplantat, Minneapolis, MN USA
[4] Univ Minnesota, Masonic Canc Ctr, Radiat Oncol, Minneapolis, MN USA
关键词
D O I
10.1016/j.annonc.2021.08.1350
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
965MO
引用
收藏
页码:S834 / S834
页数:1
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  • [1] B7H3-targeted tri-specific killer engagers deliver IL-15 to NK cells but not T-cells, and specifically target solid tumors as a pan-tumor antigen strategy mediated through NK cells
    Miller, J. S.
    Zorko, N.
    Merino, A.
    Phung, G.
    Khaw, M.
    Howard, P.
    Hamsher, H.
    Davis, Z.
    Cichocki, F.
    Berk, G. I.
    Felices, M.
    ANNALS OF ONCOLOGY, 2022, 33 (07) : S889 - S889