Viral and Host Factors Regulating HIV-1 Envelope Protein Trafficking and Particle Incorporation

被引:8
|
作者
Anokhin, Boris
Spearman, Paul [1 ]
机构
[1] Cincinnati Childrens Hosp Med, Div Infect Dis, Med Ctr, 3333 Burnet Ave, Cincinnati, OH 45229 USA
来源
VIRUSES-BASEL | 2022年 / 14卷 / 08期
关键词
envelope glycoprotein; Gag protein; recycling; endocytosis; AP-2; complex; AP-1; Rab11-FIP1C; retromer; HUMAN-IMMUNODEFICIENCY-VIRUS; CLATHRIN ADAPTER COMPLEXES; C-TERMINAL TAIL; GP41 CYTOPLASMIC TAIL; TYPE-1; ENVELOPE; SIGNAL PEPTIDE; GLYCOPROTEIN INCORPORATION; INTERNALIZATION SIGNAL; TRANSMEMBRANE PROTEIN; OLIGOMERIC STRUCTURE;
D O I
10.3390/v14081729
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The HIV-1 envelope glycoprotein (Env) is an essential structural component of the virus, serving as the receptor-binding protein and principal neutralizing determinant. Env trimers are incorporated into developing particles at the plasma membrane of infected cells. Incorporation of HIV-1 Env into particles in T cells and macrophages is regulated by the long Env cytoplasmic tail (CT) and the matrix region of Gag. The CT incorporates motifs that interact with cellular factors involved in endosomal trafficking. Env follows an unusual pathway to arrive at the site of particle assembly, first traversing the secretory pathway to the plasma membrane (PM), then undergoing endocytosis, followed by directed sorting to the site of particle assembly on the PM. Many aspects of Env trafficking remain to be defined, including the sequential events that occur following endocytosis, leading to productive recycling and particle incorporation. This review focuses on the host factors and pathways involved in Env trafficking, and discusses leading models of Env incorporation into particles.
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页数:19
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