Measuring insulin sensitivity in postmenopausal women covering a range of glucose tolerance:: comparison of indices derived from the oral glucose tolerance test with the euglycemic-hyperinsulinemic clamp

被引:25
|
作者
Piche, Marie-Eve
Lemieux, Simone
Corneau, Louise
Nadeau, Andre
Bergeron, Jean
Weisnagel, S. John
机构
[1] Univ Laval, Inst Nutraceut & Funct Foods, Quebec City, PQ, Canada
[2] Univ Laval, Div Kinesiol, Quebec City, PQ, Canada
[3] CHU Laval, Res Ctr, Diabet Res Unit, Quebec City, PQ, Canada
[4] CHU Laval, Res Ctr, Lipid Res Ctr, Quebec City, PQ, Canada
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 2007年 / 56卷 / 09期
关键词
D O I
10.1016/j.metabol.2007.04.002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study compares indices of insulin sensitivity derived from fasting and oral glucose tolerance test (OGTT) glucose and insulin measurements, with respect to the reference measure (M/I), obtained from the euglycemic-hyperinsulinemic clamp, in postmenopausal Women with varying glucose tolerance status. Fasting plasma insulin index, homeostasis model assessment index, and OGTT-derived indices (insulin 120-minute, Matsuda, metabolic clearance rate [MCR] of glucose, insulin sensitivity [ISI], and Cederholm indices) were calculated and compared with the M/I value in 112 postmenopausal women. All indices examined were significantly correlated with M/I (0.28 < r(2) < 0.56). Association studies revealed that on average, 48%, of women, were grouped in the same tertile of insulin sensitivity when using M/I and fasting plasma insulin index, and 54% when using M/I and insulin 120-minute index. However, concordance with M/I tertiles were 57%, 58%, 64%, 64%, and 68% for homeostasis model assessment, Matsuda, MCR, ISI, and Cederholm indices, respectively. Finally, correlation coefficients between M/I and insulin sensitivity indices were generally lower in women with normal glucose tolerance compared with women with impaired glucose tolerance or type 2 diabetes mellitus. These results Suggest that in postmenopausal women, surrogate indices of insulin sensitivity obtained from OGTT data and incorporating a measurement of body weight or body mass index) (Cederholm, ISI, and MCR indices) appear to be superior to those without OGTT data or body weight-body mass index measurements and, therefore, could offer a better estimate of insulin sensitivity, allowing an improved clinical evaluation of this population at higher risk of cardiovascular disease and type 2 diabetes mellitus. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:1159 / 1166
页数:8
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