Robust variation in infant gut microbiome assembly across a spectrum of lifestyles

被引：85

作者：

Olm, Matthew R. ^{[1
]}

Dahan, Dylan ^{[1
]}

Carter, Matthew M. ^{[1
]}

Merrill, Bryan D. ^{[1
]}

Yu, Feiqiao B. ^{[2
]}

Jain, Sunit ^{[2
]}

Meng, Xiandong ^{[3
]}

Tripathi, Surya ^{[4
]}

Wastyk, Hannah ^{[1
]}

Neff, Norma ^{[2
]}

Holmes, Susan ^{[1
,5
]}

Sonnenburg, Erica D. ^{[1
]}

Jha, Aashish R. ^{[6
]}

Sonnenburg, Justin L. ^{[1
,2
]}

机构：

[1] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA

[2] Chan Zuckerberg Biohub, San Francisco, CA 94158 USA

[3] Stanford Univ, ChEM H Inst, Stanford, CA 94305 USA

[4] Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA

[5] Stanford Univ, Dept Stat, Stanford, CA 94305 USA

[6] New York Univ Abu Dhabi, Program Biol, Genet Heritage Grp, Abu Dhabi, U Arab Emirates

来源：

SCIENCE | 2022年 / 376卷 / 6598期

关键词：

LONGUM SUBSP INFANTIS; UTILIZATION GENES; HADZA; TOOL; ALIGNMENT; DYNAMICS; QUALITY; AGE;

D O I：

10.1126/science.abj2972

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Infant microbiome assembly has been intensely studied in infants from industrialized nations, but little is known about this process in nonindustrialized populations. We deeply sequenced infant stool samples from the Hadza hunter-gatherers of Tanzania and analyzed them in a global meta-analysis. Infant microbiomes develop along lifestyle-associated trajectories, with more than 20% of genomes detected in the Hadza infant gut representing novel species. Industrialized infants-even those who are breastfedhave microbiomes characterized by a paucity of Bifidobacterium infantis and gene cassettes involved in human milk utilization. Strains within lifestyle-associated taxonomic groups are shared between motherinfant dyads, consistent with early life inheritance of lifestyle-shaped microbiomes. The populationspecific differences in infant microbiome composition and function underscore the importance of studying microbiomes from people outside of wealthy, industrialized nations.

引用

页码：1220 / +

页数：43

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