Evaluation of the serum-free light chain test in untreated patients with AL amyloidosis

被引：56

作者：

Bochtler, Tilmann ^{[1
]}

Hegenbart, Ute ^{[1
]}

Heiss, Christiane ^{[2
,4
]}

Benner, Axel ^{[2
]}

Cremer, Friedrich ^{[1
]}

Volkmann, Martin ^{[3
]}

Ludwig, Jochen ^{[3
]}

Perz, Jolanta B. ^{[1
]}

Ho, Anthony D. ^{[1
]}

Goldschmidt, Hartmut ^{[1
]}

Schonland, Stefan O. ^{[1
]}

机构：

[1] Heidelberg Univ, Dept Internal Med, Amyloidosis Clin, Div Hematol Oncol, Heidelberg, Germany

[2] German Canc Res Ctr, Div Biostat C060, Heidelberg, Germany

[3] Heidelberg Univ, Dept Internal Med & Clin Chem 1, Heidelberg, Germany

[4] Heidelberg Univ, Dept Internal Med, Div Hematol Oncol, Heidelberg, Germany

来源：

HAEMATOLOGICA | 2008年 / 93卷 / 03期

关键词：

serum-free light chain test; AL amyloidosis; Karnofsky index; bone marrow plasmocytosis; heart disease;

D O I：

10.3324/haematol.11687

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We evaluated the Serum Free Light Chain (FLC) test in a series of 133 untreated patients with systemic AL amyloidosis. The FLC test detected the monoclonal gammopathy in 87% compared with 92% for immunofixation of serum and urine in combination. However, both tests proved complementary. The FLC test was also a valuable tool in patients with advanced renal failure in spite of uninvolved light chain retention. Higher FLC levels were associated with higher bone marrow plasmocytosis, poorer Karnofsky index and heart involvement, and therefore reflected disease severity.

引用

页码：459 / 462

页数：4

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