Regiospecific preparation of 1,4,5-trisubstituted pyrazoles from 2-(1H-1,2,3-benzotriazol-1-yl)-3-(4-aryl)-2-propenals

被引：15
|
作者：
Katritzky, Alan R. [1 ]
Vakulenko, Anatoliy V. [1 ]
Akue-Gedu, Rufine [1 ]
Gromova, Anna V. [1 ]
Witek, Rachel [1 ]
Rogers, James W. [1 ]
机构：
[1] Univ Florida, Dept Chem, Ctr Heterocycl Compounds, Gainesville, FL 32611 USA
来源：
ARKIVOC | 2007年
关键词：
pyrazoles; regiospecific synthesis; cyclization reaction;
D O I：
10.3998/ark.5550190.0008.102
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Treatment of alpha-benzotriazolyl-alpha,beta-unsaturated aldehydes with monosubstituted hydrazines followed by alkylation at the 4- position of the pyrazoline ring and elimination of the benzotriazole group affords 1,4,5- trisubstituted pyrazoles in overall yields of 52 - 79%.
引用
收藏
页码：9 / 21
页数：13
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