Pneumolysin potentiates production of prostaglandin E2 and leukotriene B4 by human neutrophils

被引：42
|
作者：
Cockeran, R
Steel, HC
Mitchell, TJ
Feldman, C
Anderson, R
机构：
[1] Univ Pretoria, Inst Pathol, Dept Immunol, MRC,Unit Inflammat & Immun, ZA-0001 Pretoria, South Africa
[2] Johannesburg Hosp, Div Pulmonol, Johannesburg, South Africa
[3] Univ Witwatersrand, Johannesburg, South Africa
[4] Univ Glasgow, Inst Biomed & Life Sci, Div Infect & Immun, Glasgow, Lanark, Scotland
来源：
INFECTION AND IMMUNITY | 2001年 / 69卷 / 05期
关键词：
D O I：
10.1128/IAI.69.5.3494-3496.2001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent increase in the generation of prostaglandin E-2 and leukotriene B-4 by both resting and chemoattractant-activated human neutrophils in vitro. These interactions of pneumolysin with neutrophils may result in dysregulation of inflammatory responses during pneumococcal infection.
引用
收藏
页码：3494 / 3496
页数：3
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