Improvement in Renal Cystic Disease of Tuberous Sclerosis Complex After Treatment with Mammalian Target of Rapamycin Inhibitor

被引：23

作者：

Siroky, Brian J. ^{[1
,2
]}

Towbin, Alexander J. ^{[3
]}

Trout, Andrew T. ^{[3
]}

Schaefer, Hannah ^{[4
]}

Thamann, Anna R. ^{[1
]}

Agricola, Karen D. ^{[2
]}

Tudor, Cynthia ^{[2
]}

Capal, Jamie ^{[2
]}

Dixon, Bradley P. ^{[1
]}

Krueger, Darcy A. ^{[2
]}

Franz, David N. ^{[2
]}

机构：

[1] Cincinnati Childrens Hosp, Med Ctr, Div Nephrol & Hypertens, Cincinnati, OH USA

[2] Cincinnati Childrens Hosp, Med Ctr, Div Neurol, Cincinnati, OH USA

[3] Cincinnati Childrens Hosp, Med Ctr, Dept Radiol, Cincinnati, OH USA

[4] Ludwig Maximilians Univ Munchen, Div Nephrol, Munich, Germany

来源：

JOURNAL OF PEDIATRICS | 2017年 / 187卷

关键词：

POLYCYSTIC KIDNEY-DISEASE; GIANT-CELL ASTROCYTOMAS; DOUBLE-BLIND; EVEROLIMUS; ANGIOMYOLIPOMA; MULTICENTER; SIROLIMUS; FAILURE; PHASE-3; TSC2;

D O I：

10.1016/j.jpeds.2017.05.015

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Renal cysts occur in approximately 50% of patients with tuberous sclerosis complex, but their clinical significance and response to treatment are unknown. Abdominal imaging of 15 patients with tuberous sclerosis complex-associated renal cystic disease who had received mammalian target of rapamycin inhibitor therapy for other tuberous sclerosis complex-related indications was evaluated. Reductions in cyst number, sum diameter, and volume were observed.

引用

页码：318 / +

页数：7

共 50 条

[1] Mammalian Target of Rapamycin Inhibitor and Transarterial Embolization for Treatment of Tuberous Sclerosis Complex Patients with Renal Angiomyolipoma
Hsiao, Wei-Chung
Tsai, Jeng-Dau
Wang, Shao-Chun
Chen, Sung-Lang
[J]. UROLOGICAL SCIENCE, 2018, 29 (02) : 100 - 105
[2] Mammalian target of rapamycin and tuberous sclerosis complex
Wataya-Kaneda, Mari
[J]. JOURNAL OF DERMATOLOGICAL SCIENCE, 2015, 79 (02) : 93 - 100
[3] Safety Considerations of Mammalian Target of Rapamycin Inhibitors in Tuberous Sclerosis Complex and Renal Transplantation
Somers, Michael J. G.
Paul, Elahna
[J]. JOURNAL OF CLINICAL PHARMACOLOGY, 2015, 55 (04): : 368 - 376
[4] Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
Kenerson, HL
Aicher, LD
True, LD
Yeung, RS
[J]. CANCER RESEARCH, 2002, 62 (20) : 5645 - 5650
[5] Mammalian target of rapamycin inhibitor and transarterial embolization of tuberous sclerosis complex-associated renal angiomyolipoma: A case series
Hsiao, Wei-Chung
Hsieh, Tzuo-Yi
Chen, Wen-Jung
Wang, Shao-Chuan
Kao, Yu-Lin
Tsai, Jeng-Dau
Chen, Sung-Lang
[J]. INTERNATIONAL JOURNAL OF UROLOGY, 2016, 23 : 18 - 18
[6] Mammalian target of rapamycin inhibitors for the treatment of astrocytic hamartoma in tuberous sclerosis complex (TSC)
Berar, Ofri Vorobichik
Tzadok, Michal
Zloto, Ofira
Moroz, Iris
Hecht, Idan
Musika, Anne Ampaire
Shlomovitz, Omer
Fabian, Ido-Didi
Dai, Vicktoria Vishnevskia
[J]. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2022, 260 (09) : 3061 - 3068
[7] Mammalian target of rapamycin inhibitors for the treatment of astrocytic hamartoma in tuberous sclerosis complex (TSC)
Ofri Vorobichik Berar
Michal Tzadok
Ofira Zloto
Iris Moroz
Idan Hecht
Anne Ampaire Musika
Omer Shlomovitz
Ido-Didi Fabian
Vicktoria Vishnevskia Dai
[J]. Graefe's Archive for Clinical and Experimental Ophthalmology, 2022, 260 : 3061 - 3068
[8] Renal cystic disease in tuberous sclerosis complex
Kumar, Prashant
Zadjali, Fahad
Yao, Ying
Bissler, John J.
[J]. EXPERIMENTAL BIOLOGY AND MEDICINE, 2021, 246 (19) : 2111 - 2117
[9] Radiological Characteristics of Renal Lesions During Tuberous Sclerosis Complex: Impact of Mechanistic Target of Rapamycin Inhibitor Treatment
Pfirmann, Pierre
Jambon, Eva
Aupy, Jerome
Bernhard, Jean-christophe
Bakis, Hugo
Combe, Christian
Grenier, Nicolas
Rigothier, Claire
[J]. KIDNEY INTERNATIONAL REPORTS, 2022, 7 (10): : 2299 - 2302
[10] Regressed Retinal Astrocytic Hamartomas in Tuberous Sclerosis by Mammalian Target of Rapamycin Inhibitor (Everolimus) Treatment
Kim, Hyuna
Park, Song-hee
[J]. JOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY, 2021, 62 (06): : 862 - 866

← 1 2 3 4 5 →