A Site-Selective C-N Bond Formation of 2,4-Dichloro-5H-pyrano[2,3-d]pyrimidines and Amide

被引：0

作者：

Qin, Jinjing ^{[1
]}

Li, Zhenhua ^{[1
]}

Cao, Yingyan ^{[1
]}

Xie, Yuanyuan ^{[1
]}

Su, Weike ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China

来源：

CHEMISTRYSELECT | 2021年 / 6卷 / 43期

基金：

中国国家自然科学基金;

关键词：

acetanilide; amination; nucleophilic substitution; pyrano[2; 3-d]pyrimidine; ANTITUMOR-ACTIVITY; DEHYDRATION; DERIVATIVES; PYRIMIDINE; EFFICIENT; DISCOVERY; NITRILES; INSIGHT; ANALOGS; TUMOR;

D O I：

10.1002/slct.202102824

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A serious of C-4-position aniline functionalized 5H-pyrano[2,3-d]pyrimidine derivatives were synthesized from the corresponding chlorinated pyrimidines and acetanilides. This process was approached by treating the acetanilide with NaH instead of aniline, where a dissociation of the acyl group in situ happened during the reaction. The strategy worked out the non-reactive route resulted from the low reactivity of aniline. This C-N bond formation features mild reaction conditions, simple execution, and broad substrate scope.

引用

页码：12032 / 12035

页数：4

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