Immune reconstitution inflammatory syndrome versus non-immune reconstitution inflammatory syndrome lymphoma in HIV patients on antiretroviral therapy

被引：1

作者：

Choe, Pyoeng Gyun ^{[1
]}

Park, Jinyong ^{[1
]}

Park, Wan Beom ^{[1
]}

Kim, Tae Min ^{[1
]}

Song, Kyoung-Ho ^{[1
]}

Bang, Ji Hwan ^{[1
]}

Kim, Eu Suk ^{[1
]}

Park, Sang Won ^{[1
]}

Kim, Hong Bin ^{[1
]}

Kim, Nam Joong ^{[1
]}

Oh, Myoung-don ^{[1
]}

Choe, Kang Won ^{[1
]}

机构：

[1] Seoul Natl Univ, Dept Internal Med, Coll Med, 103 Daehak Ro, Seoul 03080, South Korea

来源：

INTERNATIONAL JOURNAL OF STD & AIDS | 2016年 / 27卷 / 11期

关键词：

HIV; AIDS; cancer; lymphoma; immune reconstitution inflammatory syndrome; INFECTED PATIENTS; COHORT; ERA;

D O I：

10.1177/0956462416630908

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Little is known about differences between immune reconstitution inflammatory syndrome (IRIS) and non-IRIS lymphoma in HIV patients on antiretroviral therapy (ART). The aim of this study was to describe the characteristics of IRIS and non-IRIS lymphoma in Korean HIV-positive patients on ART compared with lymphoma in those off ART. Of 1490 patients, 41 (3%) had lymphoma. Of these, 27 cases (66%) were classified as lymphoma off ART, eight as IRIS lymphoma, and six as non-IRIS lymphoma on ART. Hodgkin lymphoma was significantly more common among patients with non-IRIS lymphoma on ART than among those with lymphoma off ART (P=0.005), whereas there was no Hodgkin lymphoma among IRIS lymphoma. Stage IV lymphoma was significantly rarer in non-IRIS lymphoma on ART than in lymphoma off ART (P=0.007). Non-IRIS lymphoma on ART tends to have a better survival rate than lymphoma off ART (Kaplan-Meier survival analysis, P=0.167), while IRIS lymphoma exhibited a survival rate similar to lymphoma off ART (P=0.618). In Korean HIV-positive patients, there were significantly more cases of Hodgkin lymphoma of a less advanced stage in non-IRIS lymphoma on ART than in lymphoma off ART, in contrast to IRIS lymphoma.

引用

页码：1013 / 1015

页数：3

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