Mutagenic and carcinogenic actions of chromium and its compounds

被引：26
|
作者：
Mamyrbaev, Arstan Abdramanovich [1 ]
Dzharkenov, Timur Agataevich [1 ]
Imangazina, Zina Amangalievna [1 ]
Satybaldieva, Umit Abulkhairovna [1 ]
机构：
[1] West Kazakhstan State Med Univ, Aktobe City 030019, Kazakhstan
来源：
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE | 2015年 / 20卷 / 03期
关键词：
Chromium; Mutation; Genotoxicity; Marrow; Mammalian and human cells; The test system; Chromosomal aberrations; SISTER CHROMATID EXCHANGES; CHINESE-HAMSTER CELLS; CHROMOSOMAL-ABERRATIONS; POTASSIUM DICHROMATE; IN-VITRO; DNA; TRANSFORMATION;
D O I：
10.1007/s12199-015-0458-2
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Numerous experimental observations have been made on microorganisms and culture of the cells of mammals as well as the accounting of the chromosomal aberrations in the bone marrow cells of the mammals and of human cells displayed that the chromium and its compounds possess a pronounced mutagenic effect. Translocation test, induction record of DNA damage and repair systems in the mammalian and human cells with greater precision proves the presence of the mutagenic effect of the chromium and its compounds, which in turn is dependent on dose and time of this metal intoxication. Chromium and its compounds have pronounced mutagenic effect, on increased admission to organism of mammals and protozoa.
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页码：159 / 167
页数：9
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