Trends in Donation After Circulatory Death in Lung Transplantation in the United States: Impact Of Era

被引:26
|
作者
Bobba, Christopher M. [1 ,2 ]
Whitson, Bryan A. [2 ]
Henn, Matthew C. [2 ]
Mokadam, Nahush A. [2 ]
Keller, Brian C. [3 ]
Rosenheck, Justin [3 ]
Ganapathi, Asvin M. [2 ]
机构
[1] Univ Florida Hlth, Div Thorac & Cardiovasc Surg, Gainesville, FL USA
[2] Ohio State Univ, Dept Surg, Div Cardiac Surg, Wexner Med Ctr, Columbus, OH 43210 USA
[3] Ohio State Univ, Dept Internal Med, Div Pulm Crit Care & Sleep Med, Wexner Med Ctr, Columbus, OH 43210 USA
基金
美国国家卫生研究院;
关键词
lung transplantation; organ procurment; organ donation; donation after cardiac death; donation after brain death; CARDIOCIRCULATORY DEATH; REGISTRY; HEART; POOL;
D O I
10.3389/ti.2022.10172
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background: Use of lungs donated after circulatory death (DCD) has expanded, but changes in donor/recipient characteristics and comparison to brain dead donors (DBD) has not been studied. We examined the evolution of the use of DCD lungs for transplantation and compare outcomes to DBD lungs.Methods: The SRTR database was used to construct three 5-year intervals. Perioperative variables and survival were compared by era and for DCD vs. DBD. Geographic variation was estimated using recipient permanent address.Results: 728 DCD and 27,205 DBD lung transplants were identified. DCD volume increased from Era 1 (n = 73) to Era 3 (n = 528), representing 1.1% and 4.2% of lung transplants. Proportionally more DCD recipients were in ICU or on ECMO pre-transplant, and had shorter waitlist times. DCD donors were older, had lower PaO2/FiO2 ratios compared to DBD, more likely to be bilateral, had longer ischemic time, length of stay, post-op dialysis, and increased use of lung perfusion. There was no difference in overall survival. Geographically, use was heterogeneous.Conclusion: DCD utilization is low but increasing. Despite increasing ischemic time and transplantation into sicker patients, survival is similar, which supports further DCD use in lung transplantation. DCD lung transplantation presents an opportunity to continue to expand the donor pool.
引用
收藏
页数:10
相关论文
共 50 条
  • [1] Lung transplantation from donation after circulatory death, evolution, and current status in the United States
    Furukawa, Masashi
    Noda, Kentaro
    Chan, Ernest G.
    Ryan, John P.
    Coster, Jenalee N.
    Sanchez, Pablo G.
    CLINICAL TRANSPLANTATION, 2023, 37 (03)
  • [2] Heart transplantation using donation after circulatory death in the United States
    Chen, Qiudong
    Emerson, Dominic
    Megna, Dominick
    Osho, Asishana
    Roach, Amy
    Chan, Joshua
    Rowe, Georgina
    Gill, George
    Esmailian, Fardad
    Chikwe, Joanna
    Egorova, Natalia
    Kirklin, James K.
    Kobashigawa, Jon
    Catarino, Pedro
    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2023, 165 (05): : 1849 - 1859
  • [3] Evolution of donation after circulatory death liver transplantation in the United States
    Finotti, M.
    McKenna, G.
    Bayer, J.
    Fernandez, H.
    Lee, S. H.
    Martinez, E.
    Onaca, N.
    Ruiz, R.
    Testa, G.
    Gupta, A.
    Wall, A.
    TRANSPLANTATION, 2022, 106 (8S) : 127 - 128
  • [4] Donation after circulatory death and lung transplantation
    Reck dos Santos, Pedro Augusto
    Zimermann Teixeira, Paulo Jose
    de Moraes Neto, Daniel Messias
    Cypel, Marcelo
    JORNAL BRASILEIRO DE PNEUMOLOGIA, 2022, 48 (02)
  • [5] Donation After Circulatory Death in lung transplantation
    Van Raemdonck, Dirk
    Ceulemans, Laurens J.
    Neyrinck, Arne
    Levvey, Bronwyn
    Snell, Gregory I.
    THORACIC SURGERY CLINICS, 2022, 32 (02) : 153 - 165
  • [6] Lung Transplantation From Donation After Circulatory Death: United States and Single-Center Experience
    Villavicencio, Mauricio A.
    Axtell, Andrea L.
    Spencer, Philip J.
    Heng, Elbert E.
    Kilmarx, Sumner
    Dalpozzal, Nina
    Funamoto, Masaki
    Roy, Nathalie
    Osho, Asishana
    Melnitchouk, Serguei
    D'Alessandro, David A.
    Tolis, George
    Astor, Todd
    ANNALS OF THORACIC SURGERY, 2018, 106 (06): : 1619 - 1627
  • [7] Heart Transplantation After Donation After Circulatory Death: Early United States Experience
    Bakhtiyar, Syed Shahyan
    Sakowitz, Sara
    Mallick, Saad
    Curry, Joanna
    Benharash, Peyman
    ANNALS OF THORACIC SURGERY, 2024, 118 (02): : 484 - 493
  • [8] Evolution of Donation After Circulatory Death Liver Transplantation in the United States.
    Finotti, M.
    McKenna, G.
    Bayer, J.
    Fernandez, H.
    Lee, S.
    Martinez, E.
    Onaca, N.
    Saracino, G.
    Ruiz, R.
    Testa, G.
    Gupta, A.
    Wall, A.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2022, 22 : 730 - 730
  • [9] Donation After Circulatory Death (DCD) Lung Transplant Outcomes in the United States
    Li, S. S.
    Funamoto, M.
    Rabi, S.
    Langer, N.
    Singh, R.
    Michel, E.
    Kreso, A.
    Osho, A.
    JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2024, 43 (04): : S181 - S181
  • [10] Donation after circulatory death donors in lung transplantation
    Egan, Thomas M.
    Haithcock, Benjamin E.
    Lobo, Jason
    Mody, Gita
    Love, Robert B.
    Requard, John Jacob I. I. I. I. I. I.
    Espey, John
    Ali, Mir Hasnain
    JOURNAL OF THORACIC DISEASE, 2021, 13 (11) : 6536 - 6549