In Situ, Label-Free DNA Detection Using Organic Transistor Sensors

被引：152
|
作者：
Khan, Hadayat Ullah [1 ]
Roberts, Mark E. [2 ]
Johnson, Olasupo [2 ]
Foerch, Renate [1 ]
Knoll, Wolfgang [1 ,3 ]
Bao, Zhenan [2 ]
机构：
[1] Max Planck Inst Polymer Res, Mat Sci Grp, D-55128 Mainz, Germany
[2] Stanford Univ, Dept Chem Engn, Stanford, CA 94305 USA
[3] Austrian Inst Technol AIT GmbH, A-1220 Vienna, Austria
来源：
ADVANCED MATERIALS | 2010年 / 22卷 / 40期
基金：
美国国家科学基金会;
关键词：
SURFACE-PLASMON RESONANCE; FILMS; PROBE;
D O I：
10.1002/adma.201000790
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Organic thin-film transistors modified with 15-base PNA strands are used for the selective detection of target DNA sequences. These simple devices provide a low-cost, label-free and in situ detection platform with excellent discrimination between single and double base mismatches in the target DNA sequence. The electronic detection signal is corroborated with conventional optical methods, displaying similar hybridization parameters. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：4452 / 4456
页数：5
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