Assessing interactive mixture toxicity of carbamate and organophosphorus insecticides in the yabby (Cherax destructor)

被引:9
|
作者
Pham, Ben [1 ]
Miranda, Ana [1 ]
Allinson, Graeme [2 ]
Nugegoda, Dayanthi [1 ]
机构
[1] RMIT Univ, Sch Sci, Bundoora West Campus, Bundoora, Vic 3083, Australia
[2] RMIT Univ, Sch Sci, City Campus, Melbourne, Vic 3001, Australia
关键词
Cherax destructor; Chlorpyrifos; Malathion; methomyl; Total cholinesterase; SHRIMP PARATYA-AUSTRALIENSIS; JOINT ALGAL TOXICITY; ACETYLCHOLINESTERASE ACTIVITY; PESTICIDE MIXTURES; CHOLINESTERASE ACTIVITY; CHEMICAL-MIXTURES; RISK-ASSESSMENT; WATER; CHLORPYRIFOS; INHIBITION;
D O I
10.1007/s10646-018-1973-x
中图分类号
Q14 [生态学(生物生态学)];
学科分类号
071012 ; 0713 ;
摘要
Carbamate (CB) and organophosphorus (OP) pesticides are commonly detected in aquatic ecosystems and predominantly occur as mixtures of varying complexity. These pesticides inhibit the activity of total cholinesterase (ChE) and thus have the potential to interfere with behaviours that may be essential for the survival of aquatic species. Although the effects of individual ChE insecticides on aquatic species have been reported for decades, the neurotoxicity of mixtures is still poorly understood. This study examined the chronic toxicities of two OP insecticides (chlorpyrifos (CPF) and malathion (MAL)) and one carbamate insecticide (methomyl (METH)) in binary and ternary mixtures on the ChE activity of the yabby (C. destructor). Using the concentration addition approach to estimate mixture toxicity, the observed inhibition of ChE activity caused by all binary mixtures of CPF plus MAL, CPF plus METH and MAL plus METH was additive. In ternary mixtures, all combinations of CPF, MAL and METH were either additive or antagonistic depending on the relative ratios of these chemicals in the mixtures. The effect of mixtures of these three insecticides on C. destructor has not previously been assessed, and the data suggest that individual chemical risk assessments are likely to incorrectly estimate the effect of these insecticides on C. destructor in the aquatic environment where combinations of such chemicals occur. HighlightsAChE activity inhibition caused by both binary and tertiary mixtures was dependent on the relative ratios of these chemicals in the mixtures.All combinations of CPF, MAL and METH conformed to less than additive and antagonistic.Data suggests that individual chemical risk assessments are likely to incorrectly estimate the effect of these insecticides.
引用
收藏
页码:1217 / 1224
页数:8
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