Effects of prenatal co-administration of phentermine and dexfenfluramine in rats

被引：14
|
作者：
Bratter, J
Gessner, IH
Rowland, NE
机构：
[1] Univ Florida, Dept Psychol, Gainesville, FL 32611 USA
[2] Univ Florida, Dept Pediat, Gainesville, FL 32610 USA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 369卷 / 03期
关键词：
D O I：
10.1016/S0014-2999(99)00100-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Pregnant rats were infused with phentermine plus dexfenfluramine from days 3 through 17 of gestation. Control rats were either pair-fed or were fed ad libitum. There were no effects of prenatal drug treatment on number of offspring, their birth weights, or on their motor coordination assessed at 11 days of age. Mothers and pups were sacrificed 21 days postpartum. Drug-treated mothers, but not their pups, showed a reduced density of serotonergic axons in the hippocampus compared with controls. 25% of the pups from the prenatal drug group showed mitral valve thickening. (C) 1999 Elsevier Science B.V. All rights reserved.
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收藏
页码：R1 / R3
页数：3
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