Synthesis of sialyl Lewis X pentasaccharide analogue for high-throughput screening of selectin blockers

被引：6
|
作者：
Kiyoi, T
Inoue, Y
Ohmoto, H
Yoshida, M
Kiso, M
Kondo, H
机构：
[1] Kanebo Ltd, New Drug Res Labs, Dept Med Chem, Miyakojima Ku, Osaka 534, Japan
[2] Gifu Univ, Dept Appl Bioorgan Chem, Gifu 50011, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 1998年 / 6卷 / 05期
关键词：
D O I：
10.1016/S0968-0896(98)00003-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have developed an effective synthesis of sLe(x) pentasaccharide glycolipid analogue 2. As a part of application of sLe(x) pentasaccharide glycolipid 2 synthesized here, we have investigated the construction of a high-throughput screening system for discovery of selectin blockers. As a result, it was found that compound 2 was a useful ligand for in vitro ELISA assay and could be an important material for high-throughput screening of selectin blockers. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：587 / 593
页数：7
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