Carbon Monoxide: A Gas That Modulates Nociception

被引：25
|
作者：
Fan, Wenguo
Huang, Fang [2 ]
Wu, Zhi
Zhu, Xiao [3 ]
Li, Dongpei [3 ]
He, Hongwen [1 ]
机构：
[1] Sun Yat Sen Univ, Guanghua Sch Stomatol, Inst Stomatol Res, Dept Oral Anat & Physiol, Guangzhou 510080, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Guanghua Sch Stomatol, Dept Pediat Dent, Guangzhou 510080, Guangdong, Peoples R China
[3] Guangzhou Med Univ, Affiliated Tumor Hosp, Inst Oncol, Guangzhou, Guangdong, Peoples R China
来源：
JOURNAL OF NEUROSCIENCE RESEARCH | 2011年 / 89卷 / 06期
基金：
中国国家自然科学基金;
关键词：
carbon monoxide; heme oxygenase; nociception; review; HEME OXYGENASE TYPE-2; LONG-TERM POTENTIATION; NITRIC-OXIDE SYNTHASE; CA2+/CALMODULIN-DEPENDENT PROTEIN-KINASE; CHRONIC MORPHINE EXPOSURE; SPINAL-CORD NEURONS; FOS-LIKE PROTEIN; RAT-BRAIN; NERVOUS-SYSTEM; GLUTAMATE RECEPTORS;
D O I：
10.1002/jnr.22613
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Carbon monoxide (CO) has been recognized to act as an atypical neurotransmitter or neuromodulator in the nervous system and to be involved in a wide variety of neuronal activities. Several lines of evidence suggest that CO may play a role through multiple mechanisms in nociception processing. Differential regulation of a family of CO-generating enzymes, heme oxygenase (HO), contributes mainly to the complexity underlying the role of CO in nociception. This Mini-Review describes the latest evidence for the role of CO during normal sensory transmission and pathological pain conditions and discusses potential cellular mechanisms by which CO is involved in pathological pain. (C) 2011 Wiley-Liss, Inc.
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页码：802 / 807
页数：6
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