Anti-HER2 CAR monocytes demonstrate targeted anti-tumor activity and enable a single day cell manufacturing process.

被引：0
|
作者：
Gabitova, Linara [1 ]
Menchel, Brett [1 ]
Gabbasov, Rashid [1 ]
Pierini, Stefano [1 ]
Best, Andrew [1 ]
Ross, Kayleigh [1 ]
Ohtani, Yumi [1 ]
Blumenthal, Daniel [1 ]
Abramson, Sascha [1 ]
Condamine, Thomas [1 ]
Klichinsky, Michael [1 ]
机构：
[1] Carisma Therapeut, Philadelphia, PA USA
来源：
CANCER RESEARCH | 2021年 / 81卷 / 13期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
1530
引用
收藏
页数：2
相关论文
共 50 条
  • [1] Anti-HER2 CAR Monocytes Demonstrate Targeted Anti-Tumor Activity and Enable a Single Day Cell Manufacturing Process
    Gabitova, Linara
    Blumenthal, Daniel
    Best, Andrew
    Menchel, Brett
    Gabbasov, Rashid
    Peirini, Stefano
    Ross, Kayleigh
    Ohtani, Yumi
    Abramson, Sascha
    Condamine, Thomas
    Klichinsky, Michael
    MOLECULAR THERAPY, 2021, 29 (04) : 371 - 372
  • [2] Human CAR Monocytes Demonstrate Anti-Tumor Activity and Differentiate into M1-Polarized CAR Macrophages
    Gabrusiewicz, Konrad
    Schmierer, Maggie
    Best, Andrew
    Ohtani, Yumi
    Gabitova, Linara
    Menchel, Brett
    Abramson, Sascha
    Gill, Saar
    Klichinsky, Michael
    MOLECULAR THERAPY, 2020, 28 (04) : 502 - 502
  • [3] CT-0508 is an anti-HER2 chimeric antigen receptor (CAR) macrophage with targeted anti-tumor activity that promotes a pro-inflammatory solid tumor microenvironment
    Klichinsky, Michael
    Gabrusiewicz, Konrad
    Anderson, Nicholas
    Schmierer, Maggie
    Best, Andrew
    Zeeman, Martha
    Chhum, Sotheavy
    Ohtani, Yumi
    Shestova, Olga
    Lu, Xueqing
    Petty, Nicholas
    Shan, Xinhe
    Shen, Feng
    Gill, Saar
    CANCER RESEARCH, 2020, 80 (16)
  • [4] Genetically engineered chimeric antigen receptor (CAR) monocytes demonstrate targeted anti-tumor activity and differentiate into M1-polarized CAR macrophages
    Gabrusiewicz, Konrad
    Schmierer, Maggie
    Best, Andrew
    Zeeman, Martha
    Ohtani, Yumi
    Gabitova, Linara
    Cushing, Daniel
    Gill, Saar
    Klichinsky, Michael
    CANCER RESEARCH, 2020, 80 (16)
  • [5] A novel humanized anti-HER2 antibody conjugated with MMAE exerts potent anti-tumor activity
    Yao, Xuejing
    Jiang, Jing
    Wang, Xin
    Huang, Changjiang
    Li, Dong
    Xie, Kuan
    Xu, Qiaoyu
    Li, Hongwen
    Li, Zhuanglin
    Lou, Liguang
    Fang, Jianmin
    BREAST CANCER RESEARCH AND TREATMENT, 2015, 153 (01) : 123 - 133
  • [6] A novel humanized anti-HER2 antibody conjugated with MMAE exerts potent anti-tumor activity
    Xuejing Yao
    Jing Jiang
    Xin Wang
    Changjiang Huang
    Dong Li
    Kuan Xie
    Qiaoyu Xu
    Hongwen Li
    Zhuanglin Li
    Liguang Lou
    Jianmin Fang
    Breast Cancer Research and Treatment, 2015, 153 : 123 - 133
  • [7] Targeted tumor MRI with gadobutrol-loaded anti-HER2 immunoliposomes
    Chen, Weicui
    Liu, Bo
    Chen, Jun
    Liu, Guoqing
    Liu, Xian
    ACTA RADIOLOGICA, 2017, 58 (05) : 573 - 580
  • [8] Potent synergistic anti-tumor activity of a novel humanized anti-HER2 antibody hersintuzumab in combination with trastuzumab in xenograft models
    Shiravi, Fariba
    Mohammadi, Mehdi
    Golsaz-Shirazi, Forough
    Bahadori, Tannaz
    Judaki, Mohammad Ali
    Fatemi, Forough
    Zare, Hengameh Ahmadi
    Haghighat, Farzaneh Notash
    Mobini, Maryam
    Jeddi-Tehrani, Mahmood
    Amiri, Mohammad Mehdi
    Shokri, Fazel
    INVESTIGATIONAL NEW DRUGS, 2021, 39 (03) : 697 - 704
  • [9] Potent synergistic anti-tumor activity of a novel humanized anti-HER2 antibody hersintuzumab in combination with trastuzumab in xenograft models
    Fariba Shiravi
    Mehdi Mohammadi
    Forough Golsaz-Shirazi
    Tannaz Bahadori
    Mohammad Ali Judaki
    Forough Fatemi
    Hengameh Ahmadi Zare
    Farzaneh Notash Haghighat
    Maryam Mobini
    Mahmood Jeddi-Tehrani
    Mohammad Mehdi Amiri
    Fazel Shokri
    Investigational New Drugs, 2021, 39 : 697 - 704
  • [10] STUDY OF ANTI-HER2 CAR T CELLS IN THE IMMUNOSUPPRESSIVE EPENDYMOMA TUMOR MICROENVIRONMENT
    Nellan, Anandani
    Griesinger, Andrea
    Witt, Davis
    Donson, Andrew
    Amani, Vladimir
    Foreman, Nicholas K.
    NEURO-ONCOLOGY, 2018, 20 : 80 - 80
12345