Preparation and Sustained-release of Polymeric Drug-glucose Conjugates with NSAIDs Pendants

被引：0

作者：

Wu Chengyao ^{[1
]}

Xie Jiangang ^{[1
,2
]}

Quan Jing ^{[1
]}

Zhu Limin ^{[1
]}

机构：

[1] Donghua Univ, Shanghai 201620, Peoples R China

[2] Zhengzhou Normal Univ, Dept Chem, Zhengzhou 450016, Peoples R China

来源：

ACTA CHIMICA SINICA | 2011年 / 69卷 / 07期

关键词：

polymeric prodrug; ketoprofen; ibuprofen; naproxen; drug-saccharide conjugate; copolymer; IN-VITRO; KETOPROFEN; PRODRUGS; PEPTIDE;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An enzymatic synthesis and chemical polymerization strategy has been used to synthesize drug vinyl ester and 6-O-vinylsuccinoyl-D-glucose. Then, polymeric drug-glucose conjugates with NSAIDs (nonsteroidal anti-inflammatory drugs) pendants were prepared by the two kinds of monomers through free radical reaction using AIBN as initiator. The structures of products were characterized by IR, NMR, and GPC. In vitro release behavior of these copolymers was investigated in PBS solution (pH = 7.4) at 37 degrees C. Contrast to the parent drug, the outcome demonstrated that the polymeric prodrugs effectively prolonged the drug release rate, and the drug release rate was higher from naproxen prodrug than that of ibuprofen prodrug. The drug release behavior at various pH suggested that the drug release at alkaline medium was higher than that of acidic condition.

引用

页码：843 / 847

页数：5

共 15 条

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