Regulatory T cells and tumour immunity - observations in mice and men

被引：83
|
作者：
Gallimore, Awen [1 ]
Godkin, Andrew [1 ]
机构：
[1] Cardiff Univ, Cardiff CF14 4XN, S Glam, Wales
来源：
IMMUNOLOGY | 2008年 / 123卷 / 02期
基金：
英国医学研究理事会;
关键词：
cancer; regulation; immune surveillance;
D O I：
10.1111/j.1365-2567.2007.02748.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
An enormous body of work supports a role for CD4(+) CD25(+) regulatory cells (Tregs) in shaping the immune response to tumours. Indeed, there is evidence that the cells impede effective tumour immunosurveillance, inhibit vaccine-induced antitumour immune responses and promote tumour progression. Studies exploring the impact of Tregs on tumour development are discussed in the context of manipulating this T-cell population for the purpose of cancer immunotherapy.
引用
收藏
页码：157 / 163
页数：7
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