Synthesis of enantiomeric 9(2′,3′,4′-trihydroxybutyl)adenine derivatives from L-ascorbic and D-isoascorbic acids

被引：9
|
作者：
Wróblewski, AE [1 ]
Karolczak, W [1 ]
机构：
[1] Med Univ Lodz, Inst Chem, Fac Pharm, Bioorgan Chem Lab, PL-90151 Lodz, Poland
来源：
TETRAHEDRON | 2003年 / 59卷 / 32期
关键词：
purine acyclonucleosides; alkylation of adenine; stereoisomers;
D O I：
10.1016/S0040-4020(03)00991-8
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
(L)-Ascorbic and (D)-isoascorbic acids were employed in syntheses of 9-(2',3,4'-trihydroxybutyl)adenines protected at 3' and 4' oxygens (all four enantiomers) and at 2' oxygen (2'S,3'R and 2'S,3'S enantiomers). (C) 2003 Elsevier Ltd. All rights reserved.
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收藏
页码：6075 / 6081
页数：7
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