Improving AML Classification Using Splicing Signatures

被引：1

作者：

Bowman, Teresa V. ^{[1
,2
,3
]}

机构：

[1] Albert Einstein Coll Med, Gottesman Inst Stem Cell Biol & Regenerat Med, Dept Dev, Bronx, NY 10467 USA

[2] Albert Einstein Coll Med, Gottesman Inst Stem Cell Biol & Regenerat Med, Dept Mol Biol, Bronx, NY 10467 USA

[3] Albert Einstein Coll Med, Gottesman Inst Stem Cell Biol & Regenerat Med, Dept Med Oncol, Bronx, NY 10467 USA

来源：

CLINICAL CANCER RESEARCH | 2020年 / 26卷 / 14期

关键词：

D O I：

10.1158/1078-0432.CCR-20-1021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mutations in spliceosomal components are prevalent in myelodysplastic syndromes, but less so in acute myeloid leukemia (AML). However, aberrant splicing is prolific in AML, suggesting deregulated splicing could contribute broadly to tumorigenesis. Elevated stress responses correlate with splicing dysfunction across myeloid malignancies, representing potentially novel therapeutic targets.

引用

页码：3503 / 3504

页数：2

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