Are antibodies directed against amyloid- (A) oligomers the last call for the A hypothesis of Alzheimer's disease?

被引:53
|
作者
Panza, Francesco [1 ,2 ,3 ]
Lozupone, Madia [1 ]
Dibello, Vittorio [4 ]
Greco, Antonio [3 ]
Daniele, Antonio [5 ,6 ]
Seripa, Davide [3 ]
Logroscino, Giancarlo [1 ,2 ]
Imbimbo, Bruno P. [7 ]
机构
[1] Univ Bari Aldo Moro, Dept Basic Med Neurosci & Sense Organs, Neurodegenerat Dis Unit, Bari, Italy
[2] Univ Bari Aldo Moro, Pia Fdn Cardinale G Panico, Ctr Neurodegenerat Dis & AgingBrain, Dept Clin Res Neurol, Lecce, Italy
[3] Fdn IRCCS Casa Sollievo Sofferenza, Geriat Unit, Foggia, Italy
[4] Univ Bari Aldo Moro, Sect Dent, Interdisciplinary Dept Med DIM, Bari, Italy
[5] Univ Cattolica Sacro Cuore, Inst Neurol, Rome, Italy
[6] Fdn Policlin Univ A Gemelli IRCCS, Rome, Italy
[7] Chiesi Farmaceut, Dept Researchand Dev, Parma, Italy
关键词
aducanumab; Alzheimer's disease; BAN2401; dementia; MCI; monoclonal antibodies; passive immunotherapy; prodromal Alzheimer's disease; A-BETA; TRIAL;
D O I
10.2217/imt-2018-0119
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
[No abstract available]
引用
收藏
页码:3 / 6
页数:4
相关论文
共 50 条
  • [1] Amyloid-β hypothesis of Alzheimer's disease
    Shearman, MS
    [J]. PROGRESS IN ALZHEIMER'S AND PARKINSON'S DISEASES, 1998, 49 : 187 - 190
  • [2] Amyloid-β-directed immunotherapy for Alzheimer's disease
    Lannfelt, L.
    Relkin, N. R.
    Siemers, E. R.
    [J]. JOURNAL OF INTERNAL MEDICINE, 2014, 275 (03) : 284 - 295
  • [3] Brain amyloid-β oligomers in ageing and Alzheimer's disease
    Lesne, Sylvain E.
    Sherman, Mathew A.
    Grant, Marianne
    Kuskowski, Michael
    Schneider, Julie A.
    Bennett, David A.
    Ashe, Karen H.
    [J]. BRAIN, 2013, 136 : 1383 - 1398
  • [4] Amyloid-β oligomers in cellular models of Alzheimer's disease
    Fontana, Igor C.
    Zimmer, Aline R.
    Rocha, Andreia S.
    Gosmann, Grace
    Souza, Diogo O.
    Lourenco, Mychael, V
    Ferreira, Sergio T.
    Zimmer, Eduardo R.
    [J]. JOURNAL OF NEUROCHEMISTRY, 2020, 155 (04) : 348 - 369
  • [5] Amyloid-β oligomers as a template for secondary amyloidosis in Alzheimer's disease
    Guerrero-Munoz, Marcos J.
    Castillo-Carranza, Diana L.
    Krishnamurthy, Shashirekha
    Paulucci-Holthauzen, Adriana A.
    Sengupta, Urmi
    Lasagna-Reeves, Cristian A.
    Ahmad, Yembur
    Jackson, George R.
    Kayed, Rakez
    [J]. NEUROBIOLOGY OF DISEASE, 2014, 71 : 14 - 23
  • [6] Amyloid-β Oligomers Relate to Cognitive Decline in Alzheimer's Disease
    Jongbloed, Wesley
    Bruggink, Kim A.
    Kester, Maartje I.
    Visser, Pieter-Jelle
    Scheltens, Philip
    Blankenstein, Marinus A.
    Verbeek, Marcel M.
    Teunissen, Charlotte E.
    Veerhuis, Robert
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2015, 45 (01) : 35 - 43
  • [7] Plasma amyloid-β concentrations in Alzheimer's disease:: an alternative hypothesis
    Oprisiu, Roxana
    Serot, Jean-Marie
    Godefroy, Olivier
    Black, Sandra E.
    Fournier, Albert
    [J]. LANCET NEUROLOGY, 2006, 5 (12): : 1001 - 1002
  • [8] Plasma amyloid-β oligomers level is a biomarker for Alzheimer's disease diagnosis
    Zhou, L.
    Chan, K. H.
    Chu, L. W.
    Kwan, J. S. C.
    Song, Y. Q.
    Chen, L. H.
    Ho, P. W. L.
    Cheng, O. Y.
    Ho, J. W. M.
    Lam, K. S. L.
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 423 (04) : 697 - 702
  • [9] Amyloid-β Oligomers: Possible Role as Key Neurotoxins in Alzheimer's Disease
    Alex, Lublin L.
    Sam, Gandy
    [J]. 25TH INTERNATIONAL CONFERENCE OF ALZHEIMERS DISEASE INTERNATIONAL, 2010, : 5 - 10
  • [10] Cellular prion protein as a receptor for amyloid-β oligomers in Alzheimer's disease
    Salazar, Santiago V.
    Strittmatter, Stephen M.
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 483 (04) : 1143 - 1147