Modulation of purinergic neurotransmission by ecto-ATPase

被引：19
|
作者：
Kennedy, C
Westfall, TD
Sneddon, P
机构：
[1] Dept. of Physiology and Pharmacology, University of Strathclyde, Royal College, Glasgow G1 1XW
来源：
SEMINARS IN NEUROSCIENCE | 1996年 / 8卷 / 04期
基金：
英国惠康基金;
关键词：
ARL; 67156; ATP; ecto-ATPase; purinergic; vas deferens;
D O I：
10.1006/smns.1996.0025
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The role of ecto-ATPase in modulating the purinergic component of neurotransmission in the guinea-pig vas deferens has been investigated using ARL 67156, a recently developed inhibitor of ecto-ATPase. ARL 67156 rapidly and reversibly potentiated neurogenic contractions in a concentration-dependent manner ARL 67156 also potentiated contractions evoked by exogenous ATP, but had no effect on those to the stable analogue alpha,beta-methyleneATP or on those to noradrenaline and KCl in the presence of the P-2-purinoceptor antagonist PPADS. These results are consistent with an inhibitory action of ARL 67156 on ecto-ATPase and suggest that ecto-ATPase modulates purinergic neurotransmission in the guinea-pig vas deferens. (C) 1996 Academic Press Ltd
引用
收藏
页码：195 / 199
页数：5
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