Human gut-microbiome interplay: Analysis of clinical studies for the emerging roles of diagnostic microbiology in inflammation, oncogenesis and cancer management

被引：10

作者：

Jiang, Ziyu ^{[1
,2
]}

Li, Lingchang ^{[1
,2
]}

Chen, Jianan ^{[1
]}

Wei, Guoli ^{[1
,2
]}

Ji, Yi ^{[1
,2
]}

Chen, Xi ^{[1
,2
]}

Liu, Jingbing ^{[1
,2
]}

Huo, Jiege ^{[1
,2
]}

机构：

[1] Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Dept Oncol, Nanjing 210028, Peoples R China

[2] Jiangsu Prov Acad Tradit Chinese Med, Nanjing 210028, Peoples R China

来源：

INFECTION GENETICS AND EVOLUTION | 2021年 / 93卷

基金：

中国国家自然科学基金;

关键词：

Gut; Microbiome; Dysbiosis; Cancer; Eubiosis; NUCLEATUM PROMOTES CHEMORESISTANCE; COLORECTAL-CANCER; FUSOBACTERIUM-NUCLEATUM; HELICOBACTER-PYLORI; LACTOBACILLUS; DIET;

D O I：

10.1016/j.meegid.2021.104946

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Microorganisms have been known to coexist in various parts of human body including the gut. The interactions between microbes and the surrounding tissues of the host are critical for fine fettle of the gut. The incidence of such microorganisms tends to vary among specific type of cancer affected individuals. Such microbial communities of specific tumor sites in cancer affected individuals could plausibly be used as prognostic and/or diagnostic markers for tumors associated with that specific site. Microorganisms of intestinal and non-intestinal origins including Helicobacter pylori can target several organs, act as carcinogens and promote cancer. It is interesting to note that diets causing inflammation can also increase the cancer risk. Yet, dietary supplementation with prebiotics and probiotics can reduce the incidence of cancer. Therefore, both diet and microbial community of the gut have dual roles of prevention and oncogenesis. Hence, this review intends to summarize certain important details related to gut microbiome and cancer.

引用

页数：10