T regulatory cells, the evolution of targeted immunotherapy

被引：34
|
作者：
Nizar, S. [1 ,2 ]
Meyer, B. [1 ]
Galustian, C. [1 ]
Kumar, D. [2 ]
Dalgleish, A. [1 ]
机构：
[1] St Georges Univ London, Dept Cellular & Mol Med, London SW17 0RE, England
[2] St Georges Hosp NHS Trust, Dept Colorectal Surg, London, England
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2010年 / 1806卷 / 01期
关键词：
T regulatory; Tregs; FOXP3; Cancer; Immunotherapy; PHASE-II TRIAL; DENILEUKIN DIFTITOX; DENDRITIC CELLS; ANTITUMOR IMMUNITY; CTLA-4; BLOCKADE; TGF-BETA; PERIPHERAL-BLOOD; PROSTATE-CANCER; FUSION PROTEIN; IN-VITRO;
D O I：
10.1016/j.bbcan.2010.02.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
T regulatory cells are able to suppress anti-tumour immunity in pre-clinical models and in patients. This review highlights the important discoveries in Treg immunology critical to the evolution of targeted immunotherapy. We also describe the therapeutic applications that are currently being assessed and their future potential. (C) 2010 Elsevier BM. All rights reserved.
引用
收藏
页码：7 / 17
页数：11
相关论文
共 50 条
  • [1] Regulatory T cells as immunotherapy
    Singer, Benjamin D.
    King, Landon S.
    D'Alessio, Franco R.
    FRONTIERS IN IMMUNOLOGY, 2014, 5
  • [2] Regulatory T cells in cancer immunotherapy
    Nishikawa, Hiroyoshi
    Sakaguchi, Shimon
    CURRENT OPINION IN IMMUNOLOGY, 2014, 27 : 1 - 7
  • [3] Immunotherapy - Suppressing regulatory T cells
    McCarthy, N
    NATURE REVIEWS CANCER, 2006, 6 (01) : 6 - 7
  • [4] Regulatory T cells in the immunotherapy of melanoma
    Ouyang, Zhengxiao
    Wu, Hongwei
    Li, Linqin
    Luo, Yi
    Li, Xianan
    Huang, Gang
    TUMOR BIOLOGY, 2016, 37 (01) : 77 - 85
  • [5] Regulatory T cells in cancer immunotherapy
    Tanaka, Atsushi
    Sakaguchi, Shimon
    CELL RESEARCH, 2017, 27 (01) : 109 - 118
  • [6] Regulatory T cells in cancer immunotherapy
    Atsushi Tanaka
    Shimon Sakaguchi
    Cell Research, 2017, 27 : 109 - 118
  • [7] Immunotherapy with regulatory T cells in transplantation
    Peters, J. H.
    Koenen, H. J. P. M.
    Hilbrands, L. B.
    Joosten, I.
    IMMUNOTHERAPY, 2009, 1 (05) : 855 - 871
  • [8] T regulatory cells as an immunotherapy for transplantation
    Albert, MH
    Anasetti, C
    Yu, XZ
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2006, 6 (04) : 315 - 324
  • [9] Sublingual immunotherapy and regulatory T cells
    Ciprandi, G
    Fenoglio, D
    Cirillo, I
    Milanese, M
    Minuti, P
    ALLERGY, 2006, 61 (04) : 511 - 513
  • [10] Functional regulatory T cells and allergen immunotherapy
    Rolland, Jennifer M.
    Gardner, Leanne M.
    O'Hehir, Robyn E.
    CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 10 (06) : 559 - 566
12345