Successful Therapy of a Multidrug-Resistant Extended-Spectrum β-Lactamase-Producing and Fluoroquinolone-Resistant Salmonella enterica Subspecies enterica Serovar Typhi Infection Using Combination Therapy of Meropenem and Fosfomycin

被引：23
|
作者：
Kleine, Carola-Ellen [1 ,2 ]
Schlabe, Stefan [1 ,2 ]
Hischebeth, Gunnar T. R. [2 ,3 ]
Molitor, Ernst [2 ,3 ]
Pfeifer, Yvonne [4 ]
Wasmuth, Jan-Christian [1 ,2 ]
Spengler, Ulrich [1 ,2 ]
机构：
[1] Univ Hosp Bonn, Dept Internal Med 1, Sigmund Freud Str 25, D-53127 Bonn, Germany
[2] German Ctr Infect Res, Bonn, Germany
[3] Univ Hosp Bonn, Inst Med Microbiol Immunol & Parasitol, Bonn, Germany
[4] Robert Koch Inst, Nosocomial Infect Agents & Antibiot Resistance FG, Wernigerode, Germany
来源：
CLINICAL INFECTIOUS DISEASES | 2017年 / 65卷 / 10期
关键词：
S; Typhi; enteric fever; antibiotic resistance; carbapenems; fosfomycin; FEVER;
D O I：
10.1093/cid/cix652
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We report a traveler who acquired a Salmonella enterica subspecies enterica serovar Typhi strain with resistance against beta-lactams, cephalosporins (extended-spectrum beta-lactamase-producing type SHV-12), and quinolones (plasmid-mediated quinolone resistance gene qnrB7). After clinical deterioration using meropenem monotherapy, treatment success was achieved after commencement of fosfomycin in conjunction with high-dose meropenem. The case illustrates clinical challenges of multidrug-resistant S. Typhi.
引用
收藏
页码：1754 / 1756
页数：3
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