LPS-hyporesponsiveness of mnd mice is associated with a mutation in Toll-like receptor 4

被引：26

作者：

Bihl, F

Larivière, L

Qureshi, ST

Flaherty, L

Malo, D ^{[1
]}

机构：

[1] Montreal Gen Hosp, Ctr Study Host Resistance, Montreal, PQ H3G 1A4, Canada

[2] McGill Univ, Dept Human Genet, Montreal, PQ H3G 1Y6, Canada

[3] McGill Univ, Dept Med, Montreal, PQ H3G 1Y6, Canada

[4] Yale Univ, Sch Med, New Haven, CT 06520 USA

[5] NY State Dept Hlth, Wadsworth Ctr, Albany, NY 12208 USA

来源：

GENES AND IMMUNITY | 2001年 / 2卷 / 01期

基金：

加拿大健康研究院; 英国医学研究理事会;

关键词：

rodent; endotoxin shock; infectious immunity; bacteria; lipopolysaccharide; molecular biology;

D O I：

10.1038/sj.gene.6363732

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Toll-like receptors (Tlrs) are transmembrane proteins that have recently been shown to play a critical role in the innate immune recognition of microbial constituents. Among this family, Tlr4 is a crucial signal transducer for lipopolysaccharide (LPS), the major component of the Gram-negative bacteria outer cell membrane. In this paper, we report that C57BL/6.KB2-mnd mice, a model of neuronal ceroid lipofuscinosis, do not respond to LPS. This defect is associated with a spontaneous mutation in Tlr4 consisting of a large insertion within exon 2 predicting a frameshift mutation and a truncated protein. Genes and Immunity (2001) 2, 56-59.

引用

页码：56 / 59

页数：4

共 50 条

[1] LPS-hyporesponsiveness of mnd mice is associated with a mutation in Toll-like receptor 4
F Bihl
L Larivière
ST Qureshi
L Flaherty
D Malo
Genes & Immunity, 2001, 2 : 56 - 59
[2] LPS Mediates the Activation of Platelet by Toll-Like Receptor 4
Ma, Liping
Wei, Jing
Chang, Jian-Xing
Zhang, Cheng
Pei, Zhi-Xin
Yang, Qiu-Hong
BLOOD, 2009, 114 (22) : 1170 - 1170
[3] Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice
Kalis, C
Kanzler, B
Lembo, A
Poltorak, A
Galanos, C
Freudenberg, MA
EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (03) : 798 - 805
[4] Gene expressions of Toll-like receptor 2, but not toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages
Matsuguchi, T
Musikacharoen, T
Ogawa, T
Yoshikai, Y
JOURNAL OF IMMUNOLOGY, 2000, 165 (10): : 5767 - 5772
[5] Role of toll-like receptor 2 and toll-like receptor 4 in postischemic coronary endothelial dysfunction in mice
Favre, J
Musette, P
Henry, JP
Thuillez, C
Richard, V
CIRCULATION, 2004, 110 (17) : 34 - 34
[6] Toll-Like Receptor 2 or Toll-Like Receptor 4 Deficiency Does Not Modify Lupus in MRLlpr Mice
Freeley, Simon J.
Giorgini, Angela
Tulone, Calogero
Popat, Reena J.
Horsfield, Catherine
Robson, Michael G.
PLOS ONE, 2013, 8 (09):
[7] Absence of Toll-like receptor 4 explains endotoxin hyporesponsiveness in human intestinal epithelium
Naik, S
Kelly, EJ
Meijer, L
Pettersson, T
Sanderson, IR
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2001, 32 (04): : 449 - 453
[8] Pharmacological characterization of LPS and opioid interactions at the toll-like receptor 4
Stevens, C. W.
Aravind, S.
Das, S.
Davis, R. L.
BRITISH JOURNAL OF PHARMACOLOGY, 2013, 168 (06) : 1421 - 1429
[9] Paying the circadian toll: The circadian response to LPS injection is dependent on the Toll-like receptor 4
Paladino, Natalia
Juliana Leone, M.
Plano, Santiago A.
Golombek, Diego A.
JOURNAL OF NEUROIMMUNOLOGY, 2010, 225 (1-2) : 62 - 67
[10] Stochiometry of toll-like receptor 4 within the LPS-sensing apparatus
Triantafilou, Kathy
Triantafilou, Martha
Mouratis, Marios
Gamper, Frederick
INFLAMMATION RESEARCH, 2007, 56 : S121 - S121

← 1 2 3 4 5 →