On opportunist infections by Trypanosoma lewisi in humans and its differential diagnosis from T. cruzi and T. rangeli

被引:14
|
作者
de Sousa, Maria Auxiliadora [1 ]
机构
[1] Fiocruz MS, Inst Oswaldo Cruz, Rio De Janeiro, RJ, Brazil
关键词
Trypanosoma lewisi; Trypanosoma cruzi; Trypanosoma rangeli; Isoenzymes; PCR products; Morphology; INFANT;
D O I
10.1007/s00436-014-4132-1
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Trypanosoma lewisi is a cosmopolitan species originally found in Rattus spp., being nonpathogenic, host-restricted, and transmitted by rat fleas. This species has been recorded as an opportunist blood parasite of human beings mainly in Asia, with a case in Africa. In Brazil, this species was recently recorded in captive monkeys. As T. lewisi can share vertebrate hosts both with Trypanosoma rangeli and Trypanosoma cruzi, some markers for the differential diagnosis of these species were examined and discussed herein. The identification of T. lewisi was based on morphological features of bloodstream stages at the initial phase of infection in mammals, isoenzyme electrophoresis at the MDH locus, and PCR products of kinetoplast DNA (kDNA) minicircles using the primers TC121/TC122.
引用
收藏
页码:4471 / 4475
页数:5
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