Application of Programmable Tetrahedral Framework Nucleic Acid-Based Nanomaterials in Neurological Disorders: Progress and Prospects

被引:6
|
作者
Chen, Xingyu [1 ]
Xie, Yu [1 ]
Liu, Zhiqiang [1 ]
Lin, Yunfeng [1 ,2 ]
机构
[1] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu, Peoples R China
[2] Sichuan Univ, Coll Biomed Engn, Chengdu, Peoples R China
基金
中国国家自然科学基金;
关键词
tetrahedral framework nucleic acid; tFNA; neurological disorders; DNA nanomaterials; tetrahedral DNA nanomaterials; DNA ORIGAMI NANOSTRUCTURES; AMYLOID-BETA PEPTIDE; INTRACEREBRAL HEMORRHAGE; ALZHEIMERS-DISEASE; MECHANISMS; NANOPARTICLES; DYSFUNCTION; STABILITY; PROTEINS;
D O I
10.3389/fbioe.2021.782237
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Tetrahedral framework nucleic acid (tFNA), a special DNA nanodevice, is widely applied in diverse biomedical fields. Due to its high programmability, biocompatibility, tissue permeability as well as its capacity for cell proliferation and differentiation, tFNA presents a powerful tool that could overcome potential barriers in the treatment of neurological disorders. This review evaluates recent studies on the use and progress of tFNA-based nanomaterials in neurological disorders.
引用
收藏
页数:12
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