Study of the Behavior of Lysozyme Oligomers in Solutions by the Molecular Dynamics Method

被引：13

作者：

Kordonskaya, Yu. V. ^{[1
]}

Timofeev, V. I. ^{[1
,2
]}

Dyakova, Yu. A. ^{[1
,2
]}

Marchenkova, M. A. ^{[1
,2
]}

Pisarevsky, Yu. V. ^{[1
,2
]}

Podshivalov, D. D. ^{[1
,2
,3
]}

Kovalchuk, M. V. ^{[1
,2
,4
]}

机构：

[1] Russian Acad Sci, Shubnikov Inst Crystallog, Fed Sci Res Ctr Crystallog & Photon, Moscow 119333, Russia

[2] Natl Res Ctr, Kurchatov Inst, Moscow 123182, Russia

[3] Moscow MV Lomonosov State Univ, Moscow 119991, Russia

[4] St Petersburg State Univ, St Petersburg 199034, Russia

来源：

CRYSTALLOGRAPHY REPORTS | 2018年 / 63卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

INITIAL CRYSTALLIZATION STAGE; X-RAY-SCATTERING; PROTEIN;

D O I：

10.1134/S1063774518060196

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

The dynamics of octamers of two types, which form (via translation) a tetragonal lysozyme crystal lattice, has been simulated on a 100-ns path with and without a precipitant. It is shown that one of the octamers under study is stable in the presence of a precipitant, whereas the other octamer dissociates into components both in the presence and in the absence of a precipitant. The results obtained not only confirmed the results of previous measurements of lysozyme solutions with NaCl precipitant by small-angle X-ray neutron scattering but also made it possible to establish the type of the octamer forming in the crystallization solution.

引用

页码：947 / 950

页数：4

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V. I. Timofeev
Yu. A. Dyakova
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D. D. Podshivalov
M. V. Kovalchuk
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