Asymmetric synthesis of δ-amino acid derivatives via diastereoselective vinylogous Mannich reactions between N-tert-butanesulfinyl imines and dioxinone-derived lithium dienolate

被引：14

作者：

Li, Guijun ^{[1
,2
]}

Xu, Xiaoliang ^{[1
]}

Tian, Hongchang ^{[1
]}

Liu, Xiaotong ^{[1
]}

Chen, Wen ^{[1
]}

Yang, Xiaodong ^{[1
]}

Zhang, Hongbin ^{[1
]}

机构：

[1] Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Yunnan, Peoples R China

[2] Qujing Normal Univ, Coll Chem & Environm Sci, Qujing 655011, Yunnan, Peoples R China

来源：

RSC ADVANCES | 2017年 / 7卷 / 80期

关键词：

BETA-KETOESTERS; STEREOSELECTIVE-SYNTHESIS; HETEROCYCLIC-COMPOUNDS; ALKALOID SYNTHESIS; FORMAL SYNTHESIS; SULFINIMINES; PIPERIDINES; VINCRISTINE; CYCLIZATION; REAGENTS;

D O I：

10.1039/c7ra10529k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A diastereoselective vinylogous Mannich reaction between the N-tert-butanesulfinyl imines and dioxinone-derived lithium dienolate was developed. A variety of aldimines, ketimines and isatin-derived ketimines are suitable for this process. On the basis of X-ray crystallography of products, a predictive model for this transformation was provided.

引用

页码：50822 / 50828

页数：7

共 31 条

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