Mycoplasma pneumoniae and Chlamydia pneumoniae Coinfection with Acute Respiratory Distress Syndrome: A Case Report

被引:1
|
作者
Tsai, Meng-Ko [1 ,2 ,3 ]
Lai, Chao-Hung [4 ]
Tsai, Chris [5 ]
Chen, Guan-Liang [6 ,7 ]
机构
[1] Taichung Armed Forces Taichung Gen Hosp, Dept Internal Med, Div Allergy Immunol & Rheumatol, Taichung 41152, Taiwan
[2] Triserv Gen Hosp, Natl Def Med Ctr, Dept Internal Med, Div Allergy Immunol & Rheumatol, Taipei 11490, Taiwan
[3] Natl Def Med Ctr, Grad Inst Med Sci, Taipei 11490, Taiwan
[4] Taichung Armed Forces Gen Hosp, Dept Internal Med, Div Cardiol, Taichung 41152, Taiwan
[5] Genet Generat Adv Corp, Taipei 11490, Taiwan
[6] Taichung Armed Forces Gen Hosp, Div Chest Med & Resp Therapy, Dept Internal Med, Taichung 41152, Taiwan
[7] Triserv Gen Hosp, Natl Def Med Ctr, Dept Internal Med, Div Chest Med & Resp Therapy, Taipei 11490, Taiwan
关键词
Mycoplasma pneumoniae; Chlamydia pneumoniae; acute respiratory distress syndrome; leucine-rich repeat-containing 16A; COMMUNITY-ACQUIRED PNEUMONIA; CHLAMYDOPHILA-PNEUMONIAE; CLINICAL-FEATURES; PREVALENCE; ADULTS;
D O I
10.3390/diagnostics12010048
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Community-acquired pneumonia caused by Mycoplasma pneumoniae or Chlamydia pneumoniae is usually mild. Mycoplasma pneumoniae-related and C. pneumoniae-related acute respiratory distress syndromes (ARDSs) are rare. Moreover, to our knowledge, there are no published reports on ARDS caused by M. pneumoniae and C. pneumoniae coinfection. Here, we report a case of an immunocompetent young woman who was co-infected with M. pneumoniae and C. pneumoniae and was started on treatment with piperacillin and clarithromycin. Two days later, she developed ARDS. She recovered rapidly following a change of antibiotic treatment to levofloxacin and was discharged on day 12. We conducted exome sequencing followed by alternative filtering to search for candidate ARDS-related genes. We identified an intronic variant of unknown significance within leucine-rich repeat-containing 16A (LRRC16A), a gene previously identified as a significant locus for platelet count with a possible role in ARDS. This is a rare case of ARDS in a young adult caused by M. pneumoniae and C. pneumoniae coinfection. This case suggests that ARDS in young adults may be correlated with variants in LRRC16A. This requires confirmation by further case reports.
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页数:5
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