Association of fibrinogen and fibrinogen gene β148 and β854 polymorphisms with coronary heart disease

被引：5
|
作者：
Sun, Ai-jun [3 ,4 ]
Ma, Hui-li [3 ,7 ]
Chen, Xue-ying [3 ]
Wang, Ying [1 ,2 ]
Fang, Ye-ming [5 ]
Ma, Yong-li [6 ]
Wang, Ke-qiang [3 ]
Zou, Yun-zeng [1 ,2 ,3 ]
Huang, Wei [1 ,2 ]
Ge, Jun-bo [3 ,4 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Rui Jin hosp, Shanghai 200025, Peoples R China
[2] CHGC, Shanghai MOST Key Lab Hlth & Dis Genom, Shanghai 200025, Peoples R China
[3] Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai Inst Cardiovasc Dis, Shanghai, Peoples R China
[4] Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China
[5] Chinese Acad Tradit Chinese Med, Guanganmen Hosp, Dept Electrocardiogram, Beijing, Peoples R China
[6] Epidem Prevent Brigade Chengde City, Chengde, Peoples R China
[7] PLA, Gen Hosp Artillery 2, Dept Cardiol, Beijing, Peoples R China
来源：
CARDIOLOGY | 2008年 / 111卷 / 03期
关键词：
coronary heart disease; fibrinogen; gene beta 148/beta 854 polymorphism;
D O I：
10.1159/000121599
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: The aim of this study was to observe the association between fibrinogen C148T, G854A polymorphisms and plasma fibrinogen levels in a large cohort of Chinese patients with coronary heart disease (CHD). Methods: Fibrinogen gene beta 148/beta 854 polymorphisms were screened and plasma fibrinogen levels and lipids were measured in patients with angiographically confirmed CHD (n = 836) and in controls without CHD ( n = 418). Results: Age, sex, smoking, hypertension, diabetes mellitus, blood lipids and fibrinogen levels were related to CHD (all p < 0.05)while the frequencies of fibrinogen beta 148 and beta 854 alleles, gene and genotypes between the two groups were similar (all p > 0.05). Conclusion: This study demonstrates that the plasma fibrinogen level, but not fibrinogen beta 148 and beta 854 genotypes, was associated with CHD in the Chinese population. Copyright (c) 2008 S. Karger AG, Basel
引用
收藏
页码：167 / 170
页数：4
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