Clinical impact of the clone size in MDS cases with monosomy 7 or 7q deletion, trisomy 8, 20q deletion and loss of Y chromosome

被引：10

作者：

Mallo, Mar ^{[1
,2
]}

Luno, Elisa

Sanzo, Carmen

Cervera, Jose

Haase, Detlef

Schanze, Julie

Garcia-Manero, Guillermo ^{[3
]}

del Canizo, Consuelo

Sanz, Guillermo F.

Sole, Francesc ^{[1
]}

机构：

[1] Hosp Mar, GRETNHE, IMIM, Mol Cytogenet Lab,Dept Pathol,Res Inst, Barcelona 08003, Spain

[2] Autonomous Univ Barcelona, Fac Life Sci, Dept Cell Biol Physiol & Immunol, Bellaterra, Spain

[3] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA

来源：

LEUKEMIA RESEARCH | 2011年 / 35卷 / 06期

关键词：

Myelodysplastic syndrome; Cytogenetic; Clone burden; INSIGHTS;

D O I：

10.1016/j.leukres.2011.01.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The clone size has been postulated as a prognostic factor in myelodysplastic syndromes (MDS), though it has not been studied systematically. We tested its impact (< 100% vs. 100%) in a population of 216 MDS with chromosome 7 abnormalities (-7/7q-) (n = 84), trisomy 8 (n = 99), 20q deletion (n = 28) and loss of Y chromosome (n = 26). Focusing on the survival the bad prognosis of -7/7q- was independent of the clone size (9.3 vs. 5.0 months, P = 0.188, not significant) but trisomy 8 cases with 100% aberrant metaphases did reveal a worse prognosis (13.9 vs. 5.9 months, P = 0.003). (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：834 / 836

页数：3

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