Association of polymorphisms in glutathione-S-Transferase and DNA repair genes with ovarian cancer risk in the Russian population

被引：6
|
作者：
Khokhrin, D. V. [1 ]
Khrunin, A. V. [1 ]
Moiseev, A. A. [2 ]
Gorbunova, V. A. [2 ]
Limborska, S. A. [1 ]
机构：
[1] Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia
[2] Russian Acad Med Sci, Blokhin Russian Canc Res Ctr, Moscow 115478, Russia
来源：
RUSSIAN JOURNAL OF GENETICS | 2012年 / 48卷 / 07期
基金：
俄罗斯基础研究基金会;
关键词：
XRCC1; ERCC2;
D O I：
10.1134/S1022795412050110
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Polymorphism of glutathione-S-transferase (GSTA1, GSTM1, GSTM3, GSTP1, and GSTT1) and DNA repair (ERCC1, ERCC2, and XRCC1) genes in samples of ovarian cancer patients and healthy women of the Russian ethnic group was studied. A trend in the allele frequency variation of ERCC2 gene single nucleotide polymorphism (rs13181, A > C) was revealed. The A allele frequency was higher in the sample of patients (60,6% versus 52,9%, P = 0.058).
引用
收藏
页码：764 / 766
页数：3
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