Structure-based design and development of pyrazolopyridine-based inhibitors of Mcl-1

被引:0
|
作者
Abulwerdi, Fardokht A. [1 ]
Mady, Ahmed S. A. [1 ]
Perdih, Andrej [1 ]
Stuckey, Jeanne A. [2 ]
Showalter, Hollis D. [3 ]
Nikolovska-Coleska, Zaneta [1 ]
机构
[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI USA
[2] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Coll Pharm, Dept Med Chem, Ann Arbor, MI 48109 USA
关键词
D O I
10.1158/1538-7445.AM2014-1641
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1641
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Structure-based design of functionalized salicylates as potent Mcl-1 inhibitors
    Chen, Lijia
    Chauhan, Jay
    Yap, Jeremy
    Wilder, Paul
    Fletcher, Steven
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 249
  • [2] The discovery of Mcl-1 inhibitors using fragment-based methods and structure-based design
    Fesik, Stephen W.
    [J]. CANCER RESEARCH, 2016, 76
  • [3] Structure-based design of Mcl-1 inhibitors: Interdiction at a protein-protein interface
    Brown, Sean
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [4] Structure-based design, synthesis, and evaluation of Bcl-2/Mcl-1 dual inhibitors
    Zhu, Junjie
    Wang, Ziqian
    Guo, Zongwei
    Zhang, Xiaodong
    Song, Ting
    Guo, Yafei
    Ji, Tong
    Zhang, Zhichao
    [J]. ARCHIV DER PHARMAZIE, 2020, 353 (05)
  • [5] Discovery of selective Mcl-1 inhibitors via structure-based design and structure-activity relationship analysis
    He, Nianzhe
    Liu, Peng
    Wang, Ziqian
    Guo, Zongwei
    Yan, Xinxin
    Chen, Hongbo
    Zhang, Zhichao
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 512 (04) : 921 - 926
  • [6] Interdiction at a protein-protein interface: Structure-based design and optimization of spirocyclic Mcl-1 inhibitors
    Li, Kexue
    Brown, Sean
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [7] Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design
    Friberg, Anders
    Vigil, Dominico
    Zhao, Bin
    Daniels, R. Nathan
    Burke, Jason P.
    Garcia-Barrantes, Pedro M.
    Camper, DeMarco
    Chauder, Brian A.
    Lee, Taekyu
    Olejniczak, Edward T.
    Fesik, Stephen W.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (01) : 15 - 30
  • [8] Structure-based virtual screening, biological evaluation and biophysical study of novel Mcl-1 inhibitors
    Du, Jintong
    Liu, Lulu
    Liu, Bo
    Yang, Jing
    Hou, Xuben
    Yu, Jinming
    Fang, Hao
    [J]. FUTURE MEDICINAL CHEMISTRY, 2020, 12 (14) : 1293 - 1304
  • [9] Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors
    Johannes, Jeffrey W.
    Bates, Stephanie
    Beigie, Carl
    Belmonte, Matthew A.
    Breen, John
    Cao, Shenggen
    Centrella, Paolo A.
    Clark, Matthew A.
    Cuozzo, John W.
    Dumelin, Christoph E.
    Ferguson, Andrew D.
    Habeshian, Sevan
    Hargreaves, David
    Joubran, Camil
    Kazmirski, Steven
    Keefe, Anthony D.
    Lamb, Michelle L.
    Lan, Haiye
    Li, Yunxia
    Ma, Hao
    Mlynarski, Scott
    Packer, Martin J.
    Rawlins, Philip B.
    Robbins, Daniel W.
    Shen, Haidong
    Sigel, Eric A.
    Soutter, Holly H.
    Su, Nancy
    Troast, Dawn M.
    Wang, Haiyun
    Wickson, Kate F.
    Wu, Chengyan
    Zhang, Ying
    Zhao, Qiuying
    Zheng, Xiaolan
    Hird, Alexander W.
    [J]. ACS MEDICINAL CHEMISTRY LETTERS, 2017, 8 (02): : 239 - 244
  • [10] Pyrazolopyridine-based kinase inhibitors for anti-cancer targeted therapy
    Halder, Pallabi
    Rai, Anubhav
    Talukdar, Vishal
    Das, Parthasarathi
    Lakkaniga, Naga Rajiv
    [J]. RSC MEDICINAL CHEMISTRY, 2024, 15 (05): : 1452 - 1470