Synthesis and Antiaggregant and Anticoagulant Activity of New 1-(4-Alkyloxybenzyl)-1H-Azoles and 1-(Adamantyl-1)-2-[4-(1H-Azol-1-Ylmethyl)-Phenoxy]Ethanones

被引：2
|
作者：
Gurevich, K. G. [1 ]
Urakov, A. L. [2 ]
Basantsev, A., V [3 ]
Abzalilov, T. A. [4 ]
Bashirov, I. I. [2 ]
Danilin, A. A. [3 ]
Purygin, P. P. [2 ]
Golovanov, A. A. [5 ]
Khayrzamanova, K. A. [4 ]
Samorodov, A., V [4 ]
机构：
[1] AI Evdokimov Moscow State Univ Med & Dent, 20-1 Delegatskaya St, Moscow 127473, Russia
[2] Izhevsk State Med Acad, 281 Kommunarov St, Izhevsk 426034, Udmurtia, Russia
[3] Samara Natl Res Univ, 34 Moskovskoe Shosse, Samara 443086, Russia
[4] Bashkir State Med Univ, 3 Lenina St, Ufa 450008, Russia
[5] Togliatti State Univ, 14 Belorusskaya St, Tolyatti 445020, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2021年 / 55卷 / 08期
关键词：
4-[(1H-azol-1-yl)methyl]phenols; n-octyl bromide; n-hexadecyl bromide; (adamantyl-1)bromomethylketone; antiaggregant activity; anticoagulant activity;
D O I：
10.1007/s11094-021-02491-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The development and optimization of synthetic methods for alkyl esters of 4-[(1H-azol-1-yl)methyl]phenols enabled the expansion of organic synthesis methodology, which is extremely important for designing new structures with various types of biological activity, e.g., antiaggregant and anticoagulant. The present work studied O-alkylation of 4-[(1H-azol-1-yl)methyl]phenols with various alkylating agents, e.g., n-octyl bromide, n-hexadecyl bromide, and (adamantyl-1)bromomethylketone. The newly synthesized compounds were identified using elemental analysis and IR and PMR spectroscopy. Laboratory studies of blood isolated from healthy volunteers revealed compounds with antiaggregant and anticoagulant properties.
引用
收藏
页码：769 / 774
页数：6
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