Antileishmanial structure-activity relationships of synthetic phospholipids: In vitro and in vivo activities of selected derivatives

被引：13
|
作者：
Seifert, Karin
Lemke, Andreas
Croft, Simon L.
Kayser, Oliver
机构：
[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England
[2] Univ Groningen, Groningen, Netherlands
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 12期
关键词：
D O I：
10.1128/AAC.00465-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Antileishmanial activities of 91 synthetic phospholipids against Leishmania donovani were evaluated in vitro and cytotoxicity assessed against two mammalian cell lines. Promising compounds were tested further in vivo. In vitro structure-activity relationships showed a positive contribution of head groups bearing ring systems (N-methylpiperidino and N-methylmorpholino) to antileishmanial activity.
引用
收藏
页码：4525 / 4528
页数：4
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