Micafungin and a case of polymorphic ventricular tachycardia

被引：2

作者：

Shah, P. J. ^{[1
]}

Sundareshan, V. ^{[2
]}

Miller, B. ^{[3
]}

Bergman, S. J. ^{[4
]}

机构：

[1] HSHS St Johns Hosp, Dept Pharm, Springfield, IL USA

[2] Southern Illinois Univ, Div Infect Dis, Sch Med, Springfield, IL USA

[3] Prairie Cardiovasc, Springfield, IL USA

[4] Southern Illinois Univ Edwardsville, Sch Pharm, Dept Pharm Practice, Edwardsville, IL USA

来源：

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2016年 / 41卷 / 03期

关键词：

amiodarone; antifungal; echinocandin; micafungin; polymorphic; torsades de pointes; ventricular tachycardia; TORSADES-DE-POINTES;

D O I：

10.1111/jcpt.12386

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

What is known and objective: Although echinocandins are relatively safe antifungal drugs, cardiovascular toxicity is an emerging adverse event. This report reviews those side effects and describes a case of polymorphic ventricular tachycardia suggestive of torsades de pointes with micafungin. Case description: The patient was on micafungin for oesophageal candidiasis due to drug-drug interactions with fluconazole and amiodarone. What is new and conclusion: This is the first known case of polymorphic ventricular tachycardia with micafungin as the possible cause. Clinicians should be aware of this potential adverse event and monitor patients receiving concomitant drugs that can prolong QT interval.

引用

页码：362 / 364

页数：3

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