Syntheses, Crystal Structures and DNA-Binding Properties of Ni(II)/Zn(II)/Cd(II)/Cu(II) Complexes with 4-Methyl-1-((quinolin-8-ypmethylene)-thiosemicarbazide

被引：2
|
作者：
Mao Pan-Dong [1 ]
Han Xue-Feng [2 ]
Li Shan-Shan [1 ]
Shi Lin-Ping [1 ]
Wang Yuan [1 ]
Wu Wei-Na [1 ]
机构：
[1] Henan Polytech Univ, Coll Chem & Chem Engn, Jiaozou 454000, Henan, Peoples R China
[2] Henan Polytech Univ, Personnel Div, Jiaozuo 454000, Henan, Peoples R China
来源：
CHINESE JOURNAL OF INORGANIC CHEMISTRY | 2017年 / 33卷 / 04期
关键词：
quinoline; thiosemicarbazone; complex: crystal structure; DNA interaction; COPPER(II) COORDINATION-COMPOUNDS; BIOLOGICAL EVALUATION; TUMOR-CELLS; THIOSEMICARBAZONES; ANTICANCER; SERIES;
D O I：
10.11862/CJIC.2017.067
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Four complexes [NiL2]center dot 2CH(3)OH (1), [ZnL2]center dot CH3OH (2), [CdL2]center dot CH3CH2OH (3) and [Cu2L2Cl2] (4) (HL = 4-methyl-1-((quinolin-8-yl)methylene)-thioseinicarbazide) have been synthesized and structurally determined by single-crystal X-ray diffraction. The results show that the structures of complexes 1 similar to 3 are quite similar. The metal ion in each complex with a distorted octahedron geometry is surrounded by two anionic thiosemicarbazone ligands with N4S2 donor set. However, complex 4 is binuclear. and each central Cu(II) ion is coordinated by one independent neutral ligand HL and three chloride anions, two of which act as mu(2)-bridges. In addition, the fluorescence spectra indicate that the interactions of the complex es with DNA. particularly of the complex 4. are stronger than that of the ligand HE. CCDC: 1518183: 1: 1518184: 2; 1518185: 3; 1518186: 4.
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页码：692 / 698
页数：7
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