Association between obstructive sleep apnea and optic neuropathy: a Taiwanese population-based cohort study

被引:11
|
作者
Sun, Ming-Hui [1 ]
Liao, Yaping Joyce [2 ]
Lin, Che-Chen [3 ,4 ,5 ]
Chiang, Rayleigh Ping-Ying [6 ,7 ]
Wei, James Cheng-Chung [8 ,9 ,10 ]
机构
[1] Chang Gung Univ, Chang Gung Mem Hosp, Linkou Med Ctr, Dept Ophthalmol, Taoyuan, Taiwan
[2] Stanford Univ, Dept Ophthalmol, Stanford, CA 94305 USA
[3] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan
[4] China Med Univ, Coll Med, Taichung, Taiwan
[5] Taichung Vet Gen Hosp, HSRC, Taichung, Taiwan
[6] Taipei Med Univ, Sch Med, Dept Otolaryngol, Coll Med, Taipei, Taiwan
[7] Univ Kang Ning, Dept Nursing, Taipei, Taiwan
[8] Chung Shan Med Univ, Chung Shan Med Univ Hosp, Div Allergy Immunol & Rheumatol, Taichung, Taiwan
[9] Chung Shan Med Univ, Inst Med, Taichung, Taiwan
[10] China Med Univ, Grad Inst Integrated Med, Taichung, Taiwan
关键词
DYSFUNCTION; DISEASE;
D O I
10.1038/s41433-018-0088-1
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose Obstructive sleep apnea (OSA) is associated with many systemic diseases including diabetes, hypertension, stroke, and cardiovascular disease. The aim of our study was to investigate the association between OSA and optic neuropathy (ON), and to evaluate the efficacy of treatment for OSA on the risk of ON. Methods We used the data from the Longitudinal Health Insurance Database, which involved one million insurants from Taiwan National Health Insurance program (Taiwan NHI). Results OSA patients had a 1.95-fold higher risk of ON compared with non-OS A patients in all age group. The risk was significantly higher (adjusted hazard ratio: 4.21) in the group aged <45 years and male individuals (adjusted hazard ratio: 1.93). Meanwhile, sleep apnea was associated with ON regardless of the existence of comorbidity or not. OSA patients treated with continuous positive airway pressure (CPAP) had an adjusted 2.31-fold higher hazard of developing ON compared to controls, and those without any treatment had an adjusted 1.82-fold higher hazard of developing ON compared to controls. Moreover, ON patients had a 1.45-fold higher risk of OSA, and those aged between 45 and 64 years (hazard ratio: 1.76) and male individuals (hazard ratio: 1.55) had highest risk. Conclusions Our study showed that OSA increased the risk of developing ON after controlling the comorbidities; however, treatment with CPAP did not reduce the risk of ON. Further large population study accessing to medical records about the severity of OSA and treatment for OSA is needed to clarify the efficacy of treatment for OSA in reducing the risk of ON.
引用
收藏
页码:1353 / 1358
页数:6
相关论文
共 50 条
  • [1] Association between obstructive sleep apnea and optic neuropathy: a Taiwanese population-based cohort study
    Ming-Hui Sun
    Yaping Joyce Liao
    Che-Chen Lin
    Rayleigh Ping-Ying Chiang
    James Cheng-Chung Wei
    [J]. Eye, 2018, 32 : 1353 - 1358
  • [2] Association between obstructive sleep apnea and optic neuropathy: A Taiwanese Population-Based bidirectional cohort Study
    Sun, Ming-Hui
    Liao, Yaping Joyce
    Lin, Che-Chen
    Wei, James Cheng-Chung
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2017, 58 (08)
  • [3] Association between obstructive sleep apnea and atopic dermatitis in children: A nationwide, population-based cohort study
    Hu, Je-Ming
    Lin, Chin-Sheng
    Chen, Sy-Jou
    Chen, Chao-Yang
    Lin, Cheng-Li
    Kao, Chia-Hung
    [J]. PEDIATRIC ALLERGY AND IMMUNOLOGY, 2018, 29 (03) : 260 - 266
  • [4] THE ASSOCIATION BETWEEN OBSTRUCTIVE SLEEP APNEA AND NEUROBEHAVIOURAL FUNCTION IN MEN: A LARGE, POPULATION-BASED COHORT STUDY
    Parker, J. L.
    Adams, R. J.
    Appleton, S. L.
    Melaku, Y. A.
    Vakulin, A.
    [J]. SLEEP, 2020, 43 : A274 - A275
  • [5] Association between glycolipids and risk of obstructive sleep apnea: A population-based study
    Zheng, Murui
    Duan, Xueru
    Zhou, Huanning
    Sun, Weidi
    Sun, Guoqiang
    Chen, Jianying
    Wu, Xiuyi
    Rong, Sijing
    Huang, Jun
    Zhao, Wengjing
    Deng, Hai
    Liu, Xudong
    [J]. FRONTIERS IN NUTRITION, 2023, 10
  • [6] The association between cataract and sleep apnea: a nationwide population-based cohort study
    Liu, Pei-Kang
    Chang, Yo-Chen
    Wang, Nan-Kai
    Ryu, Joseph
    Tsai, Rong-Kung
    Hsu, Shiuh-Liang
    Hung, Jen-Yu
    Hsu, Chung-Yao
    Tai, Ming-Hong
    Tsai, Ming-Ju
    [J]. JOURNAL OF CLINICAL SLEEP MEDICINE, 2022, 18 (03): : 769 - 777
  • [7] Association between obstructive sleep apnea and heart failure in patients with and without obesity: a population-based cohort study
    Kim, K.
    [J]. EUROPEAN HEART JOURNAL, 2023, 44
  • [8] Association Between Eating Habits and Risk of Obstructive Sleep Apnea: A Population-Based Study
    Du, Yan
    Duan, Xueru
    Zheng, Murui
    Zhao, Wenjing
    Huang, Jun
    Lao, Lixian
    Weng, Fan
    Lin, Dan-Er
    Yang, Zhenxiao
    Li, Haiyi
    Liu, Xudong
    Deng, Hai
    [J]. NATURE AND SCIENCE OF SLEEP, 2021, 13 : 1783 - 1795
  • [9] The association between obstructive sleep apnea risk and cognitive disorders: a population-based study
    Shieu, Monica M.
    Dunietz, Galit Levi
    Paulson, Henry L.
    Chervin, Ronald D.
    Braley, Tiffany J.
    [J]. JOURNAL OF CLINICAL SLEEP MEDICINE, 2022, 18 (04): : 1177 - 1185
  • [10] Bidirectional association between obstructive sleep apnea and depression: A population-based longitudinal study
    Pan, Mei-Lien
    Tsao, Hsiao-Mei
    Hsu, Chien-Chi
    Wu, Kun-Ming
    Hsu, Tsan-Sheng
    Wu, Yah-Ting
    Hu, Gwo-Chi
    [J]. MEDICINE, 2016, 95 (37)