Comparison of effects of preemptive oral pregabalin-tramadol combination and parasetamol-tramadol combination administration on postoperative tramadol consumption in breast reduction surgery

Purpose: We aimed to evaluate the efficacy of preemptive oral tramadol-placebo, tramadol-pregabalin and tramadol-paracetamol combination on postoperatif tramadol consumption in patients undergoing breast reduction operation. Materials and Methods: Sixty adult patients between 1865 years of age, undergoing breast reduction surgery were included in this study, randomly divided into three groups. Each of groups were received 35 mg drop tramadol one hour before surgery. Additionally Group I (n=20) patients received 75 mg pregabalin tablet and Group II (n=20) patients received 500 mg paracetamol tablet preoperatively, and Group III (n=20) patients accepted as control group. 30 minutes before the end of operation Postoperative 24 hour pain scores, total tramadol consumption, supplement analgesic requirement, extubation, recovery time and side effects were recorded. Results: Postoperative 10th and 60th min Visual Analogue Scale scores were lower in group II compared to others. The consumption of tramadol in Group I was lower than the others when the total amount of tramadol consumtion was grouped as 120 mg >= and 120mg <. Conclusion: The combinations of pregabalin and tramadol and paracetamol and tramadol did not cause any difference in terms of postoperative pain scores, 24-hour total tramadol consumption compared with tramadol alone.