Development of Ga-68 radiolabeled DOTA functionalized and acetylated PAMAM dendrimer-coated iron oxide nanoparticles as PET/MR dual-modal imaging agent

被引：13

作者：

Almasi, Tinoosh ^{[1
]}

Gholipour, Nazila ^{[2
,3
]}

Akhlaghi, Mehdi ^{[4
]}

Mokhtari Kheirabadi, Amin ^{[4
]}

Mazidi, Seyed Mohammad ^{[5
]}

Hosseini, Seyed Hassan ^{[6
]}

Geramifar, Parham ^{[4
]}

Beiki, Davood ^{[4
]}

Rostampour, Nima ^{[1
]}

Shahbazi Gahrouei, Daryoush ^{[7
]}

机构：

[1] Kermanshah Univ Med Sci, Sch Med, Dept Radiol, Kermanshah, Iran

[2] Baqiyatallah Univ Med Sci, Syst Biol & Poisonings Inst, Chem Injuries Res Ctr, Tehran, Iran

[3] Baqiyatallah Univ Med Sci, Fac Pharm, Tehran, Iran

[4] Univ Tehran Med Sci, Res Ctr Nucl Med, Tehran, Iran

[5] Nucl Sci & Technol Res Inst NSTRI, Radiat Applicat Res Sch, Tehran, Iran

[6] Univ Sci & Technol Mazandaran, Dept Chem Engn, Behshahr, Iran

[7] Isfahan Univ Med Sci, Sch Med, Dept Med Phys, Esfahan, Iran

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2021年 / 70卷 / 15期

基金：

美国国家科学基金会;

关键词：

Gallium-68; iron oxide nanoparticles; PET; MR imaging agent; poly(amidoamide) dendrimer; radiolabeling; MAGNETIC NANOPARTICLES; BIODISTRIBUTION; CYTOTOXICITY; CLEARANCE; OPTIMIZATION; STRATEGIES; DIAGNOSIS; TOXICITY; CONTRAST; COMPLEX;

D O I：

10.1080/00914037.2020.1785451

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Gallium-68 radiolabeled DOTA- acetyl-PAMAM coated iron oxide nanoparticles (NPs) were developed as dual-modality agents for PET-MR imaging. The increase in the chelator content, acetylation step, and radiolabeling condition had distinctive effects on the physical, biological, and radiochemical properties of NPs. The r2 relaxivity coefficient value of the NPs was 96.7 mM(-1)s(-1). High accumulation of candidate NPs was in the liver and spleen and about 3.4% ID/g uptake (tissue sampling), and a distinctive uptake (PET-CT image) were observed in the tumor site. These NPs could be used as the dual-modality agent for the diagnosis of the tumors via PET-MR imaging.

引用

页码：1077 / 1089

页数：13

共 11 条

[1] Functionalized Iron Oxide Nanoparticles for Both Dual-Modal Imaging and Erythropoiesis
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[2] Lipid-coated iron oxide nanoparticles for dual-modal imaging of hepatocellular carcinoma
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[3] Development of Ga-68 labeled, biotinylated thiosemicarbazone dextran-coated iron oxide nanoparticles as multimodal PET/MRI probe
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[4] Chelator-free Radiolabeling of Iron Oxide Nanoparticles with 68Ga For Dual-Modality PET/MR Imaging
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Gallo, J.
Tsoukalas, C.
Xanthopoulos, S.
Paravatou-Petsotas, M.
Stampoulos, D.
Bonobre-Lopez, M.
Bouziotis, P.
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[5] Multifunctional iron oxide-carbon hybrid nanoparticles for targeted fluorescent/MR dual-modal imaging and detection of breast cancer cells
Han, Cuiping
Zhang, Aiwei
Kong, Ying
Yu, Nana
Xie, Ting
Dou, Binru
Li, Ke
Wang, Yong
Li, Jingjing
Xu, Kai
ANALYTICA CHIMICA ACTA, 2019, 1067 : 115 - 128
[6] Fast synthesis and bioconjugation of 68Ga core-doped extremely small iron oxide nanoparticles for PET/MR imaging
Pellico, Juan
Ruiz-Cabello, Jesus
Saiz-Alia, Marina
del Rosario, Gilberto
Caja, Sergio
Montoya, Maria
Fernandez de Manuel, Laura
Puerto Morales, M.
Gutierrez, Lucia
Galiana, Beatriz
Enriquez, Jose A.
Herranz, Fernando
CONTRAST MEDIA & MOLECULAR IMAGING, 2016, 11 (03) : 203 - 210
[7] Polyaspartic Acid-Coated Paramagnetic Gadolinium Oxide Nanoparticles as a Dual-Modal T1 and T2 Magnetic Resonance Imaging Contrast Agent
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Yue, Huan
Ghazanfari, Adibehalsadat
Ho, Son Long
Park, Ji Ae
Kim, Soyeon
Cha, Hyunsil
Liu, Shuwen
Tegafaw, Tirusew
Ahmad, Mohammad Yaseen
Al Saidi, Abdullah Khamis Ali
Zhao, Dejun
Liu, Ying
Chae, Kwon-Seok
Chang, Yongmin
Lee, Gang Ho
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[8] Combined Magnetomotive ultrasound, PET/CT, and MR imaging of 68Ga-labelled superparamagnetic iron oxide nanoparticles in rat sentinel lymph nodes in vivo
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Rene in’t Zandt
Gustav Grafström
Hanna Toftevall
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[9] Combined Magnetomotive ultrasound, PET/CT, and MR imaging of 68Ga-labelled superparamagnetic iron oxide nanoparticles in rat sentinel lymph nodes in vivo
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Cinthio, Magnus
Andersson, Roger
Tran, Thuy A.
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Grafstrom, Gustav
Toftevall, Hanna
Fredriksson, Sarah
Ingvar, Christian
Strand, Sven-Erik
Jansson, Tomas
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[10] Ga-68-labeled superparamagnetic iron oxide nanoparticles (SPIONs) for multi-modality PET/MR/Cherenkov luminescence imaging of sentinel lymph nodes
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Tran, Thuy A.
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