Dynamics of Parasite Clearance in Cutaneous Leishmaniasis Patients Treated with Miltefosine

被引：24
|
作者：
Dorlo, Thomas P. C. [1 ,2 ]
van Thiel, Pieter P. A. M. [1 ]
Schoone, Gerard J. [3 ]
Stienstra, Ymkje [1 ]
van Vugt, Michele [1 ]
Beijnen, Jos H. [2 ]
de Vries, Peter J. [1 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Div Infect Dis, NL-1105 AZ Amsterdam, Netherlands
[2] Slotervaart Hosp, Netherlands Canc Inst, Dept Pharm & Pharmacol, Amsterdam, Netherlands
[3] Royal Trop Inst, KIT Biomed Res, Parasitol Unit, NL-1105 AZ Amsterdam, Netherlands
来源：
PLOS NEGLECTED TROPICAL DISEASES | 2011年 / 5卷 / 12期
关键词：
VISCERAL LEISHMANIASIS; CLINICAL-TRIAL; QUANTIFICATION; AMPLIFICATION; SEQUENCE; PCR;
D O I：
10.1371/journal.pntd.0001436
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Parasite loads were quantified in repeated skin biopsies from lesions of 2 patients with Old-World cutaneous leishmaniasis (CL) caused by Leishmania major and L. infantum during and after treatment with miltefosine. Miltefosine induced a rapid therapeutic effect on both infections with an initial decline of parasites of similar to 1 log/week for the L. major infection. These observations illustrate the usability of quantifying parasite loads in skin lesions as a pharmacodynamic measure and quantitative descriptor of drug effect for CL supporting clinical assessment.
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页数：5
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