Electrically Conductive Gold-Coated Collagen Nanofibers for Placental-Derived Mesenchymal Stem Cells Enhanced Differentiation and Proliferation

被引:92
|
作者
Orza, Anamaria [1 ]
Soritau, Olga [2 ]
Olenic, Liliana [3 ]
Diudea, Mircea [1 ]
Florea, Adrian [4 ]
Ciuca, Dan Rus [4 ]
Mihu, Carmen [4 ]
Casciano, Daniel [5 ]
Biris, Alexandru S. [5 ]
机构
[1] Univ Babes Bolyai, Fac Chem & Chem Engn, R-3400 Cluj Napoca, Romania
[2] Oncol Inst Prof Dr Ion Chiricuta, Cluj Napoca, Romania
[3] Natl Inst Res & Dev Isotop & Mol Technol, Cluj Napoca, Romania
[4] Iuliu Hatieganu Univ Med & Pharm, Cluj Napoca, Romania
[5] Univ Arkansas, Nanotechnol Ctr, Little Rock, AR 72204 USA
关键词
collagen; gold-coated collagen fibers; stem cell differentiation and proliferation; NANOPARTICLES; GROWTH; NANOMATERIALS; BINDING; CARBON;
D O I
10.1021/nn1035312
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Gold-coaled collagen nanofibers (GCNFs) were produced by a single-step reduction process and used for the growth and differentiation of human adult stem cells. The nanomaterials were characterized by a number of analytical techniques including electron microscopy and spectroscopy. They were found to be biocompatible and to Improve the myocardial and neuronal differentiation process of the mesenchymal stem cells isolated from the placental chorionic component. The expression of specific differentiation markers (atrium, natriuretic peptide, actin F and actin monomer, glial fibrilary addic protein, and neurofilaments) was investigated by immunocytochernistry.
引用
收藏
页码:4490 / 4503
页数:14
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