Can tranexamic acid reduce the blood transfusion rate in patients undergoing percutaneous nephrolithotomy? A systematic review and meta-analysis

被引:7
|
作者
Wang, Zhenghao [1 ]
He, Xiao [2 ]
Bai, Yunjin [1 ]
Wang, Jia [1 ]
机构
[1] Sichuan Univ, Inst Urol, West China Hosp, Dept Urol, Chengdu, Peoples R China
[2] Sichuan Univ, West China Sch Med, West China Clin Skills Training Ctr, Chengdu, Peoples R China
关键词
Tranexamic acid; blood transfusion; percutaneous nephrolithotomy; randomized controlled trial; meta-analysis; blood loss; hemoglobin; DOUBLE-BLIND; INTRAOPERATIVE USE; SURGERY; PROSTATECTOMY; FIBRINOLYSIS; MANAGEMENT;
D O I
10.1177/0300060520917563
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objective A systematic review and meta-analysis was conducted to explore the efficacy of tranexamic acid (TXA) in reducing transfusion events in patients undergoing percutaneous nephrolithotomy (PCNL). Methods PubMed, Web of Science, Embase, EBSCO, and Cochrane library databases from January 1980 to October 2019 were searched for randomized controlled trials (RCTs) that assessed TXA efficacy in reducing transfusion events during PCNL. Intervention treatments include using TXA compared with placebo (or no intervention) for patients who underwent PCNL. The search strategy and study selection process were managed in accordance with the PRISMA statement. Results Six RCTs are included in the meta-analysis. Overall, TXA intervention groups showed a significant reduction in blood transfusion events (RR = 0.34; 95% confidence interval [CI] = 0.19 to 0.62), hemoglobin decrease (MD = -0.80; 95% CI = -1.32 to -0.28), operative time (MD = -12.62; 95% CI = -15.62 to -9.61), and length of hospital stay (MD = -0.73; 95% CI = -1.36 to -0.10) compared with control groups after PCNL. However, TXA had no substantial impact on the rate of stone clearance (RR = 1.10; 95% CI = 1.00 to 1.21). Conclusions TXA can effectively reduce the transfusion rate and blood loss during PCNL.
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页数:10
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