Immunological bases of increased susceptibility to invasive nontyphoidal Salmonella infection in children with malaria and anaemia

被引:12
|
作者
Nyirenda, Tonney S. [1 ,2 ]
Mandala, Wilson L. [2 ,3 ,4 ]
Gordon, Melita A. [2 ,5 ]
Mastroeni, Pietro [6 ]
机构
[1] Univ Malawi, Coll Med, Pathol Dept, Blantyre, Malawi
[2] Malawi Liverpool Wellcome Trust Clin Res Programm, Blantyre, Malawi
[3] Univ Malawi, Coll Med, Biomed Sci Dept, Blantyre, Malawi
[4] Malawi Univ Sci & Technol, Acad Med Sci, Limbe, Malawi
[5] Univ Liverpool, Inst Infect & Global Hlth, Liverpool, Merseyside, England
[6] Univ Cambridge, Dept Vet Med, Cambridge, England
基金
英国惠康基金; 英国生物技术与生命科学研究理事会;
关键词
Salmonella; Malaria; Children; Anaemia; Immunity; Susceptibility; ENTERICA SEROVAR TYPHIMURIUM; NON-TYPHOIDAL SALMONELLA; NITRIC-OXIDE SYNTHASE; NADPH PHAGOCYTE OXIDASE; BLOOD-STREAM INFECTIONS; NECROSIS-FACTOR-ALPHA; IFN-GAMMA PRODUCTION; DENDRITIC CELLS; T-CELLS; INTRACELLULAR-DISTRIBUTION;
D O I
10.1016/j.micinf.2017.11.014
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Malaria and anaemia are key underlying factors for iNTS disease in African children. Knowledge of clinical and epidemiological risk-factors for iNTS disease has not been paralleled by an in-depth knowledge of the immunobiology of the disease. Herein, we review human and animal studies on mechanisms of increased susceptibility to iNTS in children. (C) 2017 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur.
引用
收藏
页码:589 / 598
页数:10
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