Development and validation of a LC-FL method for the simultaneous determination of doxorubicin and celecoxib in nanoparticulate fixed dose combination (NanoFDC)

被引：4
|
作者：
Kozlu, S. [1 ]
Sahin, A. [1 ]
Calis, S. [1 ]
Capan, Y. [1 ]
机构：
[1] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06100 Ankara, Turkey
来源：
PHARMAZIE | 2017年 / 72卷 / 10期
关键词：
LIQUID-CHROMATOGRAPHY; HUMAN PLASMA; CANCER;
D O I：
10.1691/ph.2017.7077
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An isocratic reversed phase HPLC method for the simultaneous determination of doxorubicine (DOX) and celecoxib (CXB) out of a nanoparticulate fixed dose combination (NanoFDC) was developed and validated. Linearity of the results was demonstrated from 1-11 mu g/mL for both components. Lower limits of detection were determined as 7 ng/mL for DOX and 13 ng/mL for CXB. Total run time was approximately 15 min.
引用
收藏
页码：568 / 570
页数：3
相关论文
共 50 条
  • [1] Development and Validation of RP-LC Method for the Simultaneous Determination of Simvastatin and Ezetimibe in Fixed-Dose Combination Tablets and in Rabbit Serum
    Sevinc Kurbanoglu
    Ozgur Esim
    Cansel Kose Ozkan
    Ayhan Savaser
    Yalcin Ozkan
    Sibel A. Ozkan
    Chromatographia, 2019, 82 : 279 - 285
  • [2] Development and Validation of RP-LC Method for the Simultaneous Determination of Simvastatin and Ezetimibe in Fixed-Dose Combination Tablets and in Rabbit Serum
    Kurbanoglu, Sevinc
    Esim, Ozgur
    Ozkan, Cansel Kose
    Savaser, Ayhan
    Ozkan, Yalcin
    Ozkan, Sibel A.
    CHROMATOGRAPHIA, 2019, 82 (01) : 279 - 285
  • [3] Development and validation of an HPLC method for the simultaneous determination of artesunate and mefloquine hydrochloride in fixed-dose combination tablets
    Andrade Nogueira, Fernando Henrique
    Araujo Reis, Naialy Fernandes
    Chellini, Paula Rocha
    Cesar, Isabela da Costa
    Pianetti, Gerson Antonio
    BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2013, 49 (04) : 837 - 843
  • [4] Development and Validation of Stability-Indicating RP-Hplc Method for Simultaneous Determination of Canagliflozin and Metformin in Fixed-Dose Combination
    Khan, Nayeem
    Ahmed, Aejaz
    Qazi, Majaz
    Ansari, Yaasir Ahmed
    Shaikh, Afsar
    Badgire, Ayyaj A.
    Salman, Mohd
    Khan, Noosrat Jahan
    JOURNAL OF RESEARCH IN PHARMACY, 2023, 27 (03): : 1234 - 1241
  • [5] Development and Validation of a Novel Stability-Indicating RP-HPLC Method for Simultaneous Determination of Tezacaftor and Ivacaftor in Fixed Dose Combination
    Singh, Narendra
    Bansal, Parveen
    Maithani, Mukesh
    Chauhan, Yashpal
    JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2020, 58 (04) : 346 - 354
  • [6] Development and validation of a stability-indicating RP-HPLC method for simultaneous determination of dapagliflozin and saxagliptin in fixed-dose combination
    Singh, N.
    Bansal, P.
    Maithani, M.
    Chauhan, Y.
    NEW JOURNAL OF CHEMISTRY, 2018, 42 (04) : 2459 - 2466
  • [7] HPLC Method Development and Validation for the Determination of Apixaban and Clopidogrel in Novel Fixed-Dose Combination Tablets
    Al-Shami, Ni'meh
    Naseef, Hani
    Moqadi, Ramzi
    Kanaze, Feras
    JOURNAL OF CHEMISTRY, 2024, 2024
  • [8] Development and validation of HPTLC method for simultaneous analysis of Tramadol HCl and paracetamol in fixed-dose combination tablets
    Patil, V. P.
    Kawde, R. V.
    Kurhade, S. D.
    Devdhe, S. J.
    Kale, S. H.
    Patil, A. A.
    Wakte, P. S.
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2013, 90 (06) : 745 - 750
  • [9] Development and validation of an analytical method for simultaneous determination of fixed-dose combination tablets of lamivudine, zidovudine and nevirapine by high performance liquid chromatography
    Maciel Lavra, Zenia Maria
    Rolim Neto, Pedro Jose
    Ferreira da Silva, Rosali Maria
    Morais de Medeiros, Flavia Patricia
    QUIMICA NOVA, 2008, 31 (05): : 969 - 974
  • [10] Development and Validation of Stability-Indicating RP-HPLC Method for Simultaneous Determination of Metformin HCl and Glimepiride in Fixed-Dose Combination
    Vaingankar, Pradnya N.
    Amin, Purnima D.
    ANALYTICAL CHEMISTRY INSIGHTS, 2016, 11
12345