Circulating tumour DNA (ctDNA) as a liquid biopsy for melanoma

被引：84
|
作者：
Calapre, Leslie [1 ]
Warburton, Lydia [2 ]
Millward, Michael [2 ,3 ]
Ziman, Mel [1 ,4 ]
Gray, Elin S. [1 ]
机构：
[1] Edith Cowan Univ, Sch Med Sci, Joondalup, WA, Australia
[2] Sir Charles Gairdner Hosp, Dept Med Oncol, Nedlands, WA, Australia
[3] Univ Western Australia, Sch Med & Pharmacol, Crawley, WA, Australia
[4] Univ Western Australia, Sch Pathol & Lab Med, Crawley, WA, Australia
来源：
CANCER LETTERS | 2017年 / 404卷
关键词：
Melanoma; Liquid biopsy; ctDNA; Circulating tumour DNA; Cell-free DNA; CELL-FREE DNA; TERT PROMOTER MUTATIONS; MUTATED METASTATIC MELANOMA; DROPLET DIGITAL PCR; FREE PLASMA DNA; ACQUIRED-RESISTANCE; EPIGENETIC INACTIVATION; METHYLATION PATTERNS; CHECKPOINT BLOCKADE; SUPPRESSOR GENES;
D O I：
10.1016/j.canlet.2017.06.030
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Circulating tumour DNA (ctDNA) has emerged as a promising blood-based biomarker for monitoring disease status of patients with advanced cancers. In melanoma, ctDNA has been shown to have clinical value as an alternative tumour source for the detection clinically targetable mutations for the assessment of response to therapy, This review provides a critical summary of the evidence that gives credence to the utility of ctDNA as a biomarker for monitoring of disease status in advanced melanoma and the steps required for its implementation into clinical settings. (C) 2017 The Author(s). Published by Elsevier B.V.
引用
收藏
页码：62 / 69
页数：8
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